Leire
Garate Iturriagagoitia
Investigadora Colaboradora
Publicacions (43) Publicacions de Leire Garate Iturriagagoitia
2024
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An automated network-based tool to search for metabolic vulnerabilities in cancer
Nature Communications , Vol. 15, Núm. 1
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Epigenetic-based differentiation therapy for Acute Myeloid Leukemia
Nature Communications, Vol. 15, Núm. 1
2023
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Revealing cell populations catching the early stages of human embryo development in naive pluripotent stem cell cultures
Stem Cell Reports, Vol. 18, Núm. 1, pp. 64-80
2022
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Identifying Lethal Dependencies with HUGE Predictive Power
Cancers, Vol. 14, Núm. 13
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Landscape and clinical significance of long noncoding RNAs involved in multiple myeloma expressed fusion transcripts
American Journal of Hematology
2021
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Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma
Leukemia, Vol. 35, Núm. 5, pp. 1438-1450
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Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with in Vivo Efficacy in Multiple Myeloma
Journal of Medicinal Chemistry, Vol. 64, Núm. 6, pp. 3392-3426
2020
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Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma
Genome Research, Vol. 30, Núm. 9, pp. 1217-1227
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Re: Inhibition of a G9a/DNMT Network Triggers Immune-Mediated Bladder Cancer Regression
Journal of Urology
2019
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Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression
Nature Medicine
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Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response
Nature Communications, Vol. 10, Núm. 1
2018
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Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces
Journal of Medicinal Chemistry, Vol. 61, Núm. 15, pp. 6546-6573
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Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy
Journal of Medicinal Chemistry, Vol. 61, Núm. 15, pp. 6518-6545
2017
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An in-silico approach to predict and exploit synthetic lethality in cancer metabolism
Nature Communications, Vol. 8, Núm. 1
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In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer
Scientific Reports, Vol. 7, Núm. 1
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Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome
PLoS ONE, Vol. 12, Núm. 12
2013
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Erratum: ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia (Oncogene (2013) 32 (803) DOI: 10.1038/onc.2012.593)
Oncogene
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Erratum: Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia (Oncogene (2013) 32 (804) DOIi: 10.1038/onc.2012.592)
Oncogene
2012
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Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: Implications in TNFα regulation and proliferation of hematopoietic progenitor cells
Blood, Vol. 119, Núm. 13, pp. 3042-3049
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Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia (Blood (2007) 109, 8 (3462-3469))
Blood