Elixabet
Bolaños Mateo
Investigadora Colaboradora
Ignacio
Melero
Catedrático de Universidad
Ignacio Melero-rekin lankidetzan egindako argitalpenak (32)
2024
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Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 30, Núm. 18, pp. 4131-4142
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Short-term cultured tumor fragments to study immunotherapy combinations based on CD137 (4-1BB) agonism
OncoImmunology, Vol. 13, Núm. 1
2023
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Interleukin-18 in cancer immunology and immunotherapy
Expert Opinion on Therapeutic Targets, Vol. 27, Núm. 11, pp. 1035-1042
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Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity
Cancer immunology research, Vol. 11, Núm. 2, pp. 184-198
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Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists
Molecular Therapy - Nucleic Acids, Vol. 33, pp. 668-682
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Intratumoral injection of IL-12-encoding mRNA targeted to CSFR1 and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure
Molecular Therapy - Nucleic Acids, Vol. 33, pp. 599-616
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Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic
OncoImmunology, Vol. 12, Núm. 1
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mRNAs encoding IL-12 and a decoy-resistant variant of IL-18 synergize to engineer T cells for efficacious intratumoral adoptive immunotherapy
Cell Reports Medicine, Vol. 4, Núm. 3
2022
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A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα and IL-1β
Cancer Discovery, Vol. 12, Núm. 9, pp. 2140-2157
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Advances in mRNA-based drug discovery in cancer immunotherapy
Expert Opinion on Drug Discovery, Vol. 17, Núm. 1, pp. 41-53
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Novel strategies exploiting interleukin-12 in cancer immunotherapy
Pharmacology and Therapeutics, Vol. 239
2021
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Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Núm. 26
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CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation
Nature Communications, Vol. 12, Núm. 1
2020
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Cellular cytotoxicity is a form of immunogenic cell death
Journal for ImmunoTherapy of Cancer, Vol. 8, Núm. 1
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Engineering bionic T cells: signal 1, signal 2, signal 3, reprogramming and the removal of inhibitory mechanisms
Cellular and Molecular Immunology, Vol. 17, Núm. 6, pp. 576-586
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Exploiting TCR Recognition of Shared Hotspot Oncogene-encoded Neoantigens
Clinical Cancer Research, Vol. 26, Núm. 6, pp. 1203-1204
2019
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Immunotherapeutic effects of intratumoral nanoplexed poly I:C
Journal for ImmunoTherapy of Cancer, Vol. 7, Núm. 1
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Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells
Cancer cell, Vol. 36, Núm. 6, pp. 613-629
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TGFb blockade enhances radiotherapy abscopal efficacy effects in combination with anti-PD1 and anti-CD137 immunostimulatory monoclonal antibodies
Molecular Cancer Therapeutics, Vol. 18, Núm. 3, pp. 621-631
2018
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Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4–1BB)
OncoImmunology, Vol. 7, Núm. 1