Rubén
Pio Osés
Catedrático de Universidad
Centro de Investigación Biomédica en Red de Cáncer
Madrid, España
2025
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Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors
Molecular Cancer, Vol. 24, Núm. 1
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Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer
Signal Transduction and Targeted Therapy, Vol. 10, Núm. 1
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Fasting and fasting-mimicking conditions in the cancer immunotherapy era
Journal of Physiology and Biochemistry, Vol. 81, Núm. 2, pp. 383-389
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Genetic variants in complement-related genes: potential implications for cancer risk and progression
Immunobiology, Vol. 230, Núm. 4
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Insights and perspectives into the discovery of complement-related biomarkers in cancer
Current Opinion in Immunology, Vol. 96
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The C5a/C5aR1 Axis Promotes Migration of Tolerogenic Dendritic Cells to Lymph Nodes, Impairing the Anticancer Immune Response
Cancer immunology research, Vol. 13, Núm. 3, pp. 384-399
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The complement system in clinical oncology: Applications, limitations and challenges
Seminars in Immunology, Vol. 77
2024
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Elevated expression of complement factor I in lung cancer cells associates with shorter survival–Potentially via non-canonical mechanism
Translational Research, Vol. 269, pp. 1-13
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G9a/DNMT1 co-targeting inhibits non-small cell lung cancer growth and reprograms tumor cells to respond to cancer-drugs through SCARA5 and AOX1
Cell Death and Disease, Vol. 15, Núm. 11
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Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
Molecular Cancer, Vol. 23, Núm. 1
2023
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Plasma fractalkine contributes to systemic myeloid diversity and PD-L1/PD-1 blockade in lung cancer
EMBO Reports, Vol. 24, Núm. 8
2022
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C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d
Frontiers in Immunology, Vol. 13
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Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis
Cancer Letters, Vol. 529, pp. 70-84
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Design and validation of a tunable inertial microfluidic system for the efficient enrichment of circulating tumor cells in blood
Bioengineering and Translational Medicine, Vol. 7, Núm. 3
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The complement system as a regulator of tumor-promoting activities mediated by myeloid-derived suppressor cells
Cancer Letters, Vol. 549
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Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer
Cancer Discovery, Vol. 12, Núm. 5, pp. 1356-1377
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Two cell line models to study multiorganic metastasis and immunotherapy in lung squamous cell carcinoma
DMM Disease Models and Mechanisms, Vol. 15, Núm. 1
2021
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A model based on the quantification of complement C4c, CYFRA 21-1 and CRP exhibits high specificity for the early diagnosis of lung cancer
Translational Research, Vol. 233, pp. 77-91
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Molecular biomarkers in early stage lung cancer
Translational Lung Cancer Research, Vol. 10, Núm. 2, pp. 1165-1185
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Surgical Outcomes in a Lung Cancer-Screening Program Using Low Dose Computed Tomography
Archivos de Bronconeumologia, Vol. 57, Núm. 2, pp. 101-106