José Ángel
Martínez Climent
Investigador Senior
Argitalpenak (123) José Ángel Martínez Climent argitalpenak
2024
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Not so natural, not so killers
Blood
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Round Table Discussion on Optimal Clinical Trial Design in Precursor Multiple Myeloma
Blood cancer discovery, Vol. 5, Núm. 3, pp. 146-152
2023
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Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation
Blood, Vol. 141, Núm. 9, pp. 1047-1059
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Chronic docosahexaenoic acid supplementation improves metabolic plasticity in subcutaneous adipose tissue of aged obese female mice
Journal of Nutritional Biochemistry, Vol. 111
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Differential remodeling of subcutaneous white and interscapular brown adipose tissue by long-term exercise training in aged obese female mice
Journal of Physiology and Biochemistry, Vol. 79, Núm. 2, pp. 451-465
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Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
Nature Communications, Vol. 14, Núm. 1
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Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
Nature Medicine, Vol. 29, Núm. 3, pp. 632-645
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Targeting the immune microenvironment in Waldenström macroglobulinemia via halting the CD40/CD40-ligand axis
Blood, Vol. 141, Núm. 21, pp. 2615-2628
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Venetoclax improves CD20 immunotherapy in a mouse model of MYC/BCL2 double-expressor diffuse large B-cell lymphoma
Journal for immunotherapy of cancer, Vol. 11, Núm. 2
2022
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Preneoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma
Science Advances, Vol. 8, Núm. 3
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The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma
Blood, Vol. 139, Núm. 3, pp. 384-398
2021
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Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- And high-risk myeloma
Blood, Vol. 137, Núm. 1, pp. 49-60
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Endogenous retroelement activation by epigenetic therapy reverses the warburg effect and elicits mitochondrial-mediated cancer cell death
Cancer Discovery, Vol. 11, Núm. 5, pp. 1268-1285
2020
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B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
Leukemia, Vol. 34, Núm. 4, pp. 1158-1162
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CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation
Blood Advances, Vol. 4, Núm. 5, pp. 893-906
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Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL
Leukemia, Vol. 34, Núm. 10, pp. 2722-2735
2019
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PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas
Blood, Vol. 133, Núm. 22, pp. 2401-2412
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The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models
Nature Communications, Vol. 10, Núm. 1
2018
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Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces
Journal of Medicinal Chemistry, Vol. 61, Núm. 15, pp. 6546-6573
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Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy
Journal of Medicinal Chemistry, Vol. 61, Núm. 15, pp. 6518-6545