Manuela
González Aparicio
Researcher to 2023


Centro de Investigación Médica Aplicada
Pamplona, EspañaPublications in collaboration with researchers from Centro de Investigación Médica Aplicada (16)
2024
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Characterization of brain transduction capability of a BBB-penetrant AAV vector in mice, rats and macaques reveals differences in expression profiles
Gene Therapy, Vol. 31, Núm. 9-10, pp. 455-466
2021
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Adenovirus-mediated inducible expression of a pd-l1 blocking antibody in combination with macrophage depletion improves survival in a mouse model of peritoneal carcinomatosis
International Journal of Molecular Sciences, Vol. 22, Núm. 8
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AdrA as a Potential Immunomodulatory Candidate for STING-Mediated Antiviral Therapy That Required Both Type I IFN and TNF-α Production
Journal of immunology (Baltimore, Md. : 1950), Vol. 206, Núm. 2, pp. 376-385
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Local administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma
Molecular Therapy - Oncolytics, Vol. 20, pp. 23-33
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Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations
Molecular Therapy - Nucleic Acids, Vol. 25, pp. 585-602
2019
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Danio rerio as model organism for adenoviral vector evaluation
Genes, Vol. 10, Núm. 12
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Influence of interleukin-8 and neutrophil extracellular trap (NET) formation in the tumor microenvironment: Is there a pathogenic role?
Journal of Immunology Research, Vol. 2019
2018
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Inhibition of adenovirus infection by mifepristone
Antiviral Research, Vol. 159, pp. 77-83
2017
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Adaptation of vectors and drug-inducible systems for controlled expression of transgenes in the tumor microenvironment
Journal of Controlled Release, Vol. 268, pp. 247-258
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X-box Binding Protein 1 Regulates Unfolded Protein, Acute-Phase, and DNA Damage Responses During Regeneration of Mouse Liver
Gastroenterology, Vol. 152, Núm. 5, pp. 1203-1216.e15
2015
2013
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Helper-dependent adenoviral liver gene therapy protects against induced attacks and corrects protein folding stress in acute intermittent porphyria mice
Human Molecular Genetics, Vol. 22, Núm. 14, pp. 2929-2940
2012
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Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B
Hepatology, Vol. 56, Núm. 2, pp. 474-483
2011
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Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice
Gut, Vol. 60, Núm. 3, pp. 341-349
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Self-inactivating helper virus for the production of high-capacity adenoviral vectors
Gene Therapy, Vol. 18, Núm. 11, pp. 1025-1033