Publications in collaboration with researchers from Centro de Investigación Médica Aplicada (9)

2022

  1. Mechanistic modelling of enzyme-restoration effects of new recombinant liver-targeted proteins in acute intermittent porphyria

    British Journal of Pharmacology, Vol. 179, Núm. 14, pp. 3815-3830

2021

  1. Semi-mechanistic model for the antitumor response of a combination cocktail of immuno-modulators in non-inflamed (Cold) tumors

    Cancers, Vol. 13, Núm. 20

2020

  1. Disease pharmacokinetic–pharmacodynamic modelling in acute intermittent porphyria to support the development of mRNA-based therapies

    British Journal of Pharmacology, Vol. 177, Núm. 14, pp. 3168-3182

2013

  1. Mathematical model approach to describe tumour response in mice after vaccine administration and its applicability to immune-stimulatory cytokine-based strategies

    AAPS Journal, Vol. 15, Núm. 3, pp. 797-807

  2. Modeling tumor response after combined administration of different immune-stimulatory agentss

    Journal of Pharmacology and Experimental Therapeutics, Vol. 346, Núm. 3, pp. 432-442

  3. Target-mediated disposition model describing the dynamics of IL12 and IFNγ after administration of a mifepristone-inducible adenoviral vector for IL-12 expression in mice

    AAPS Journal, Vol. 15, Núm. 1, pp. 183-194

2012

  1. Kinetic and dynamic computational model-based characterization of new proteins in mice: Application to interferon alpha linked to apolipoprotein A-I

    PLoS ONE, Vol. 7, Núm. 7

  2. The fusion protein of IFN-α and apolipoprotein A-I crosses the blood-brain barrier by a saturable transport mechanism

    Journal of Immunology, Vol. 188, Núm. 8, pp. 3988-3992

2010

  1. Gene therapy: A pharmacokinetic/pharmacodynamic modelling overview

    Pharmaceutical Research, Vol. 27, Núm. 8, pp. 1487-1497