A Biomimetic Approach to Lanthionines
- Aydillo, C. 1
- Avenoza, A. 1
- Busto, J.H. 1
- Jiménez-Osés, G. 12
- Peregrina, J.M. 1
- Zurbano, M.M. 1
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1
Universidad de La Rioja
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2
University of California Los Angeles
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ISSN: 1523-7060
Any de publicació: 2012
Volum: 14
Número: 1
Pàgines: 334-337
Tipus: Article
Altres publicacions en: Organic Letters
Resum
The asymmetric sulfa-Michael additions of appropriately protected l- and d-cysteine derivatives to new chiral dehydroamino acid derivatives have been developed as key steps in the synthesis of biologically important cysteine derivatives, such as lanthionine (Lan) and β-methyllanthionine (MeLan), which are unusual bis-α-amino acids found in the emerging lantibiotics such as nisin. © 2011 American Chemical Society.