Utilidad del col11a1 como marcador pronóstico de infiltración tumoral

Abstract

Small samples, burned areas, or tumor cell deficits can lead to underdiagnosis in pathological diagnosis. COL11A1, which is expressed only in invasive lesions, appears to be a good candidate for the determination of the malignant potential of tumor lesions. Breast, colon, bladder, ovary, renal, lung and melanoma tumor populations have been selected. Immunohistochemistry was performed against pro-COL11A1. Data obtained from breast, colon, bladder and ovary samples present a high sensitivity in the differential expression of the COL11A1 marker in infiltrating versus non-infiltrating samples. In renal cancer, the expression was associated with a poor prognosis. In melanoma and lung, COL11A1 expression did not have a significant impact on diagnosis. The expression of COL11A1, therefore, is a very accurate marker in the diagnosis of tumor invasiveness with a very high sensitivity in a large number of tumor types and should be introduced in daily diagnostic practice.