Derivados de 1,4-di-N-óxido de quinoxalina y enfermedades olvidadas

Abstract

Neglected diseases are diseases that affect thousands of people around the world, but who do not have effective or suitable treatments. They are mainly infectious tropical diseases that fundamentally affect the poorest population; some examples are tuberculosis, leishmaniasis, malaria and Chagas, which generate a devastating impact on humanity. This fact highlights the necessity to search for new economically accessible therapies for the affected population. Throughout the years our research group has carried out the design and synthesis of several quinoxaline 1,4-di-N-oxide derivatives with the aim of finding new leaders for the treatment of these types of diseases by means of simple, low cost synthetic methods. This work has resulted in the development of new active structures such as antitubercular, antimalarial and antichagas agents, and more recently, antileishmania agents. This summary displays the most important results obtained in this field, and it may be concluded that the quinoxaline 1,4-di-N-oxide nucleus represents a possible advance in the search of new active compounds.