El Registro Molecular de Adenomas Hipofisarios (REMAH)una apuesta de futuro de la Endocrinología española por la medicina individualizada y la investigación traslacional

  1. Raúl M. Luque 16
  2. Alejandro Ibáñez-Costa 16
  3. Laura Sánchez-Tejada 10
  4. Esther Rivero-Cortés 16
  5. Mercedes Robledo 17
  6. Ainara Madrazo-Atutxa 6
  7. Mireia Mora 1
  8. Clara V. Álvarez 18
  9. Tomás Lucas-Morante 2
  10. Cristina Álvarez-Escolá 3
  11. Carmen Fajardo 4
  12. Luis Castaño 5
  13. Sonia Gaztambide 5
  14. Eva Venegas-Moreno 6
  15. Alfonso Soto-Moreno 6
  16. María Ángeles Gálvez 7
  17. Javier Salvador 8
  18. Elena Valassi 9
  19. Susan M. Webb 9
  20. Antonio Picó 10
  21. Manel Puig-Domingo 11
  22. Montserrat Gilabert 12
  23. Ignacio Bernabéu 13
  24. Mónica Marazuela 14
  25. Alfonso Leal-Cerro 15
  26. Justo P. Castaño 16
  27. Show all authors +
  1. 1 Hospital Clínic i Universitari de Barcelona. Unitat d'Endocrinologia
  2. 2 Hospital Universitario Puerta de Hierro
    info

    Hospital Universitario Puerta de Hierro

    Madrid, España

    ROR https://ror.org/01e57nb43

  3. 3 Hospital Universitario La Paz
    info

    Hospital Universitario La Paz

    Madrid, España

    ROR https://ror.org/01s1q0w69

  4. 4 Hospital Universitari de La Ribera. Servei d'Endocrinologia
  5. 5 Hospital Universitario de Cruces
    info

    Hospital Universitario de Cruces

    Barakaldo, España

    ROR https://ror.org/03nzegx43

  6. 6 IBiS. Unidad de Gestión Clínica de Endocrinología y Nutrición
  7. 7 Hospital Universitario Reina Sofia
    info

    Hospital Universitario Reina Sofia

    Córdoba, España

    ROR https://ror.org/02vtd2q19

  8. 8 Clínica Universitaria de Navarra
    info

    Clínica Universitaria de Navarra

    Pamplona, España

    ROR https://ror.org/03phm3r45

  9. 9 Hospital de la Santa Creu i Sant Pau
    info

    Hospital de la Santa Creu i Sant Pau

    Barcelona, España

    ROR https://ror.org/059n1d175

  10. 10 Hospital General Universitari d'Alacant. Departament d'Endocrinologia
  11. 11 Hospital Universitari Germans Trias i Pujol
    info

    Hospital Universitari Germans Trias i Pujol

    Barcelona, España

    ROR https://ror.org/04wxdxa47

  12. 12 Novartis Farmacéutica
  13. 13 Complexo Hospitalario Universitario de Santiago
    info

    Complexo Hospitalario Universitario de Santiago

    Santiago de Compostela, España

    ROR https://ror.org/00mpdg388

  14. 14 Hospital Universitario de la Princesa
    info

    Hospital Universitario de la Princesa

    Madrid, España

    ROR https://ror.org/03cg5md32

  15. 15 IBiS
  16. 16 Instituto Maimónides de Investigación Biomédica de Córdoba
    info

    Instituto Maimónides de Investigación Biomédica de Córdoba

    Córdoba, España

    ROR https://ror.org/00j9b6f88

  17. 17 Centro Nacional de Investigaciones Oncológicas
    info

    Centro Nacional de Investigaciones Oncológicas

    Madrid, España

    ROR https://ror.org/00bvhmc43

  18. 18 CIMUS
Show affiliations +
Journal:
Endocrinología y nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición

ISSN: 1575-0922

Year of publication: 2016

Volume: 63

Issue: 6

Pages: 274-284

Type: Article

DOI: 10.1016/J.ENDONU.2016.03.001 DIALNET GOOGLE SCHOLAR

More publications in: Endocrinología y nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición

Sustainable development goals

Abstract

Pituitary adenomas are uncommon, difficult to diagnose tumors whose heterogeneity and low incidence complicate large-scale studies. The Molecular Registry of Pituitary Adenomas (REMAH) was promoted by the Andalusian Society of Endocrinology and Nutrition (SAEN) in 2008 as a cooperative clinical-basic multicenter strategy aimed at improving diagnosis and treatment of pituitary adenomas by combining clinical, pathological, and molecular information. In 2010, the Spanish Society of Endocrinology and Nutrition (SEEN) extended this project to national level and established 6 nodes with common protocols and methods for sample and clinical data collection, molecular analysis, and data recording in a common registry (www.remahnacional.com). The registry combines clinical data with molecular phenotyping of the resected pituitary adenoma using quantitative real-time PCR of expression of 26 genes: Pituitary hormones (GH-PRL-LH-FSH-PRL-ACTH-CGA), receptors (somatostatin, dopamine, GHRH, GnRH, CRH, arginine-vasopressin, ghrelin), other markers (Ki67, PTTG1), and control genes. Until 2015, molecular information has been collected from 704 adenomas, out of 1179 patients registered. This strategy allows for comparative and relational analysis between the molecular profile of the different types of adenoma and the clinical phenotype of patients, which may provide a better understanding of the condition and potentially help in treatment selection. The REMAH is therefore a unique multicenter, interdisciplinary network founded on a shared database that provides a far-reaching translational approach for management of pituitary adenomas, and paves the way for the conduct of combined clinical-basic innovative studies on large patient samples.

Data source: Dialnet