Efectos de citalopram, reboxetina y nefazodona sobre diversas preparaciones de órgano aislado de cobaya t de rata "in vitro"

Zusammenfassung

Citalopram, reboxetine and nefazodone are antidepressants which mainly inhibit serotonin (5-HT) reuptake, other interactions have been described. Therefore, the effects of citalopram, reboxetine and nefazodone on noradrenaline (NA), dopamine (DA), or K+ - contracted rat vas deferens have studied. The effects on 5-HT, oxytocin and K+-induced contractions in rat uterus and those on histamine (H), acetylcholine (Ach), 4-aminopyridine (4-AP) and K+-contractions in guinea-pig ileum were also studied. Krebs-Henseleit solution with and without adding cocaine, 17 beta estradiol and propranolol was used for rat vas deferens tissues. Jalon solution for rat uterus and Tyrode solution for guinea-pig ileum. When possible pD'2 values were calculated. CONCLUSIONS: Citalopram inhibited contractions induced by Ach (pD'2 = 4.3 ± 0.3), H (pD'2 = 5.3 ± 0.4), 4-AP (pD'2 = 5.4 ± 0.4), and potassium (pD'2 = 4.3 ± 0.3) in guinea-pig ileum; 5-HT (pD'2 = 3.5 ± 0.3), oxytocin (pD'2 = 4.8 ± 0.3) and potassium (pD'2 = 4.2 ± 0.3) in rat uterus. Reboxetine inhibited contractions induced by 5-HT (pD'2 = 5.1 ± 0.4), oxytocin (pD'2 = 4.9 ± 0.3) and potassium (pD'2 = 5.1 ± 0.4) in rat uterus; DA (pD'2 = 4.6 ± 0.4) in rat vas deferens. Nefazodone inhibited contractions induced by Ach (pD'2 = 5.3 ± 0.3), H (pD'2 = 5.3 ± 0.4), 4-AP (pD'2 = 5.2 ± 0.3) and potassium (pD'2 = 5.2 ± 0.4) in guinea-pig ileum; 5-HT (pD'2 = 7.0 ± 0.5), oxytocin (pD'2 = 5.2 ± 0.4), and potassium (pD'2 = 5.2 ± 0.4) in rat uterus; NA pD'2 = 2.4 ± 0.1), DA (pD'2 = 5.2 ± 0.4) and potassium (pD'2 = 4.4 ± 0.4) in rat vas deferens. Other interactions were not statistically significant.