Influencia de variantes genéticas en la respuesta ponderal a la cirugía bariátrica

Résumé

Bariatric surgery (BS) achieves substantial and persistent effects on weight loss in patients with morbid obesity (MO) and improves the management of obesity-associated comorbidities. Thereis inter-individual variability in weight response after BS, with estimates of aproximately 15-35% of patients failing to achieve their weight loss goal in the short term and 10-80 % of patients regaining a significant portion of their weight loss in the long term. The pathophysiology of obesity and the response to BS involve complex interactions between biological and hormonal, environmental, behavioural and genetic factors that regulate body weight. Genome-wide association studies have identified more than 300 polymorphisms involved in eating behaviour and energy expenditure, associated with Body Mass Index (BMI) and adiposity traits, however,in BS intervention, studies are very limited. The primary objective of our work is to identify genetic markers associated with MO and genetic markers associated with weight loss and its long-term maintenance after different BS surgical techniques. The genetic variants analysed encode for gastrointestinal peptides, their receptors or proteins involved in their expression, involved in appetite control and metabolism...