PET de doble fase con 18F-FDOPA como instrumento para la caracterización de tumores cerebrales
- M. González-Forero
- Elena Prieto Azcárate
- Inés Domínguez Prado
- Carmen Vigil Díaz
- Iván Peñuelas Sánchez
- Javier Arbizu Lostao
ISSN: 0212-6982
Année de publication: 2011
Volumen: 30
Número: 2
Pages: 88-93
Type: Article
D'autres publications dans: Revista española de medicina nuclear
Objectifs de Développement Durable
Résumé
18F-FDOPA is an amino acid analogue used to evaluate presynaptic dopaminergic activity, which has aroused great interest in neuro-oncology. We have evaluated five 18F-FDOPA PET studies of patients referred for study of parkinsonian syndrome. Two subjects had previously treated high-grade brain tumors, one nonspecific brain injury, and 2 subjects presented unexpected tumoral lesions. For all lesions SUVmax, time to SUVmax and tumor-to-normal grey matter SUVmax rate (T/N) were calculated, and 90minutes 18F-FDOPA kinetics were analyzed. Tumor lesions corresponded to three malignant neurocytomas, one meningioma, one pineocytoma and one intrasinusal hemangioma. Both malignant and benign tumors exhibited high uptake of 18F-FDOPA well above the normal cortex. However, the analysis of the curve uptake displayed characteristic patterns that facilitate the characterization of tumor lesions. A dual phase maximum uptake was observed, with an early 10minutes uptake in malignant lesions, and a late 60 to 90minutes uptake in benign or low grade lesions.