Quantification of dosimetric uncertainties in lung stereotactic body radiation therapy

  1. Huesa Berral, Carlos
Supervised by:
  1. Javier Burguete Director
  2. Juan Diego Azcona Armendáriz Director

Defence university: Universidad de Navarra

Fecha de defensa: 13 September 2021

  1. Jan-Jakob Sonke Chair
  2. Josep María Martí Climent Secretary
  3. Pedro Arce Dubois Committee member
  4. Benigno Barbés Fernández Committee member
  5. Yolanda Prezado Alonso Committee member
  1. (FC) Física y Matemática Aplicada

Type: Thesis

Teseo: 156253 DIALNET lock_openDadun editor


Lung stereotactic body radiation therapy (SBRT) is associated with sources of geometric uncertainties, such as respiratory motion, daily anatomical variations (anatomical baseline shifts between daily and planned position) and the simultaneous movement between the tumor and the multileaf collimator (the so-called interplay effect) during treatment delivery. In this work, several methodologies have been implemented based on deformable image registration to quantify the dosimetric impact of those geometric uncertainties in lung SBRT. These methodologies revealed two main conclusions: First, daily anatomical deviations in patient anatomy generally had a larger dosimetric impact than respiratory motion. Second, the impact of interplay effect could be a concern for highly irregular patient breathing patterns or for long breathing periods, and whether small field size were used for dose conformation purposes. Furthermore, these methodologies developed would be very helpful for clinicians involved in treatment planning and delivery to evaluate treatment robustness against the geometric uncertainties studied in this work.