Long-Term Outcome of Critically Ill Advanced Cancer Patients Managed in an Intermediate Care Unit
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Fernández Ros, Nerea
- Alegre, Félix
- Rodríguez Rodriguez, Javier 2
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Landecho, Manuel F.
- Sunsundegui, Patricia
- Gúrpide, Alfonso
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Lecumberri, Ramón
- Sanz, Eva
- García, Nicolás
- Quiroga, Jorge
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Lucena, Juan Felipe
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1
Universidad de Navarra
info
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2
Clínica Universitaria de Navarra
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3
Instituto de Investigación Sanitaria de Navarra
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Instituto de Investigación Sanitaria de Navarra
Pamplona, España
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4
Universidad Europea de Madrid
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5
Centro de Investigación Biomédica en Red sobre Enfermedades Hepáticas y Digestivas
info
Centro de Investigación Biomédica en Red sobre Enfermedades Hepáticas y Digestivas
Madrid, España
ISSN: 2077-0383
Ano de publicación: 2022
Volume: 11
Número: 12
Páxinas: 3472
Tipo: Artigo
Outras publicacións en: Journal of Clinical Medicine
Obxectivos de Desenvolvemento Sustentable
Resumo
Background: To analyze the long-term outcomes for advanced cancer patients admitted to an intermediate care unit (ImCU), an analysis of a do not resuscitate orders (DNR) subgroup was made. Methods: A retrospective observational study was conducted from 2006 to January 2019 in a single academic medical center of cancer patients with stage IV disease who suffered acute severe complications. The Simplified Acute Physiology Score 3 (SAPS 3) was used as a prognostic and severity score. In-hospital mortality, 30-day mortality and survival after hospital discharge were calculated. Results: Two hundred and forty patients with stage IV cancer who attended at an ImCU were included. In total, 47.5% of the cohort had DNR orders. The two most frequent reasons for admission were sepsis (32.1%) and acute respiratory failure (excluding sepsis) (38.7%). Mortality in the ImCU was 10.8%. The mean predicted in-hospital mortality according to SAPS 3 was 51.9%. The observed in-hospital mortality was 37.5% (standard mortality ratio of 0.72). Patients discharged from hospital had a median survival of 81 (30.75–391.25) days (patients with DNR orders 46 days (19.5–92.25), patients without DNR orders 162 days (39.5–632)). The observed mortality was higher in patients with DNR orders: 52.6% vs. 23.8%, p 0 < 0.001. By multivariate logistic regression, a worse ECOG performance status (3–4 vs. 0–2), a higher SAPS 3 Score and DNR orders were associated with a higher in-hospital mortality. By multivariate analysis, non-invasive mechanical ventilation, higher bilirubin levels and DNR orders were significantly associated with 30-day mortality. Conclusion: For patients with advanced cancer disease, even those with DNR orders, who suffer from acute complications or require continuous monitoring, an ImCU-centered multidisciplinary management shows encouraging results in terms of observed-to-expected mortality ratios.
Información de financiamento
This research received no external fundingReferencias bibliográficas
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