Sex differences in ochratoxin A nephrotoxicityA molecular approach to the mechanism of action

  1. Pastor Castro, Laura
Dirigida per:
  1. Adela López de Cerain Salsamendi Directora
  2. Ariane Vettorazzi Armental Codirectora

Universitat de defensa: Universidad de Navarra

Data de defensa: 05 de juliol de 2017

Tribunal:
  1. María Pilar Lostao Crespo Presidenta
  2. Paul Cordero Secretari/ària
  3. Francisco Javier Campión Zabalza Vocal
  4. Fermín Ignacio Milagro Yoldi Vocal
  5. Eduardo de la Peña Torres Vocal
Centro académico (Área Salud, Experimentales y Técnicas): Facultad de Farmacia y Nutrición (FFN)
Departamento académico (Área Salud, Experimentales y Técnicas): (FFN) Ciencias Farmacéuticas
Organización: Universidad de Navarra

Tipus: Tesi

Teseo: 122795 DIALNET HANDLE: https://hdl.handle.net/10171/43768
Dadun. Depósito Académico Digital de la Universidad de Navarra: lock_openAccés obert Handle

Resum

This work is included in the line of research carried out in Toxicology which studies the mycotoxin ochratoxin A (OTA) from the point of view of its mechanism of action. OTA causes various toxic effects, such as nephrotoxicity, hepatotoxicity, immunosuppression, neurotoxicity and teratogenicity. However, the main issue concerning OTA effect is its carcinogenic potential in kidney, the target organ. The aim of this research project was to explore the impact of sex on OTA-induced gene expression response in order to determine the key events that might be involved in the early events of the carcinogenic process.