Screening de primer trimestre de preeclampsia tardía en gestantes de bajo riesgo en un centro de bajo volumen obstétricovalidación externa de un modelo predictivo
- Díaz Cobos, D. F. 1
- Laparte Escorza, C. 1
- Ruiz Zambrana, A. 1
- Alcazar, J. L. 1
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1
Clínica Universitaria de Navarra
info
ISSN: 1137-6627
Year of publication: 2015
Volume: 38
Issue: 3
Pages: 387-396
Type: Article
More publications in: Anales del sistema sanitario de Navarra
Abstract
Background. The external validation of predictive model of late preeclampsia in a low volume and low risk obstetrical setting. Methods. A cohort was created of 174 singleton pregnancies of 11+0-13+6 gestational weeks at Clinica Universidad Navarra from September 2011 to March 2013, which was considered as a validation cohort of a previously described model for late PE (Hospital Clinic, Barcelona). Results. A total of 7 (4%) women developed late PE. In the validation cohort the area under the curve of the model was 0.69 (95% CI 0.45-0.93). Detection rates for a 5, 10 and 15% of false positive rates were 21.9, 31.4% and 38.6% respectively. When comparing the areas under the curve of the validation cohort with the construction cohort, no statistical differences were found (p=0.68). Conclusion. The combination of maternal history, pregnancy associated plasma protein-A and mean arterial pressure is moderately useful to predict preeclampsia in a low risk and low volume obstetrical setting. The predictive model of the Clinic Hospital of Barcelona is a valid tool in predicting late preeclampsia in this setting.