Susceptibilidad genética en cáncer de colon

  1. Zabalegui, M.
  2. Zarate, Ruth
  3. Catalán, V.
  4. Honorato, B.
  5. García, F.
  6. Garcia Foncillas, Jesús
  7. Hernández, J.L.
  8. Bandrés, E.
Revue:
Revista de medicina

Année de publication: 2003

Volumen: 47

Número: 1

Pages: 20-23

Type: Article

Résumé

The occurrence of cancer is occasionally explained by genetic alterations. In order to distinguish between a sporadic or hereditary cancer, it becomes necessary to identify a defined mutation on a single gene within the germinal line. Most of the known familial syndromes are autosomic dominant inherited. Frequently, the genes implicated in these disorders are tumor suppressor genes (APC associated with FAP and, MLH1 and MSH2 associated with HNPCC). In the hereditary cases, genetic study of the family is strongly recommended. Moreover, detection of the family mutations could help us understand better the behavior of the cancer.