Estrógenos y desarrollo del cerebro femenino en la adolescenciaanticoncepción de emergencia

  1. López Moratalla, Natalia
  2. Errasti Alcalá, Tania
  3. Santiago Calvo, Esteban
Revista:
Cuadernos de bioética

ISSN: 1132-1989 2386-3773

Año de publicación: 2011

Volumen: 22

Número: 75

Páginas: 185-200

Tipo: Artículo

Otras publicaciones en: Cuadernos de bioética

Referencias bibliográficas

  • Uhlenhaut, N.H.J., Anlag, K. S., Eisen- Uhlenhaut, N.H.J., Anlag, K. S., Eisenberger, T., Sekido, R. Kress, J., Treeier, A.C., Klugmann, C., Klasen, C., Holter, N.I., Rieter Riegethmarcher, G.S., Cooney, A.J., Lovell-Badge, R., Treier, M. «Somatic sex reprogramming of Adult Ovaries to testes by FOXL2 ablation». Cell 139, (2009), 1130-1142.
  • Gilmore, J.H., Lin, W., Prastawa, M.W., Looney, C.B., Vetsa, Y.S., Knickmeyer, R.C., Evans, D.D., Smith, J.K., Hamer, R.M., Lieberman, J.A., Gerig, G. «Regional grey matter growth, sexual dimorphism, and cerebral asymmetry in the neonatal brain». Journal of Neuroscience 27, (2007), 1255-1260.
  • Garcés, C, et al. «Hormone levels in 12- to 15-year-old boys and girls in Spain and their relationship with anthropometric variables». Clinical Biochemistry 41, (2008), 621-624.
  • Garagorri, J.M., et al. «Reference levels for 17-hydroxyprogesterone, 11-desoxycortisol, cortisol, testosterone, dehydroepi- cortisol, testosterone, dehydroepi- , testosterone, dehydroepiandrosterone sulfate and androstenedione in infants from birth to six months of age». European Journal of Pediatrics 167, (2008), 647-653.
  • Schwarz, J.M., McCarthy, M.M. «Steroidinduced sexual differentiation of the developing brain: multiple pathways, one goal». Journal of Neurochemistry 105, (2008), 1561-1572.
  • MacLusky, N.J., Hajszan, T., Prange-Kiel, J., Leranth, C. «Androgen modulation of hippocampal synaptic plasticity». Neuroscience 138, (2006), 957- 965.
  • Galea, L.A., Spritzer, M.D., Barker, J.M., Pawluski, J.L. «Gonadal hormone modulation of hippocampal neurogenesis in the adult». Hippocampus 16, (2006), 225-232.
  • Romeo, R.D., Richardson, H.N., Sisk, C.L. «Puberty and the maturation of the male brain and sexual behavior: recasting a behavioural potential». Neuroscience and Biobehavioral Reviews 26, (2002), 381-391.
  • Schwarz, J.M., McCarthy, M.M. «Steroidinduced sexual differentiation of the developing brain: multiple pathways, one goal». Journal of Neurochemistry 105, (2008), 1561-1572.
  • Jordan, K., Wüstenberg, T., Heinze, H.J., Michael, P., Jäncke, L. «Women and men exhibit different cortical activation patterns during mental rotation tasks». Neuropsychologia 40, (2002), 2397- 2408.
  • Gizewski, E.R., Krause, E., Wanke, I., Forst- Gizewski, E.R., Krause, E., Wanke, I., Forsting, M., Senf, W. «Gender-specific cerebral activation during cognitive tasks using functional MRI: comparison of women in mid-luteal phase and men». Neuroradiology 48, (2006), 14-20.
  • Rozmin, H., Sharma, T., Hines, M., Andrew, C., Simmons, A., Kumari, V. «Comparable fMRI activity with differential behavioural performance on mental rotation and overt verbal fluency tasks in healthy men and women». Exp Brain Res 169, (2006), 1-14.
  • Schulz, K.M., Molenda-Figueira, H.A., Sisk, C.L. «Back to the future: The organizationalactivational hypothesis adapted to puberty and adolescence» Hormones and Behavior 55, (2009), 597-604.
  • Sisk, C.L., Zehr, J.L. «Pubertal hormones organize the adolescent brain and behaviour». Frontiers in Neuroendocrinology 26, (2005), 163-174.
  • Friemel, C.M., Spanagel, R., Schneider, M. «Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats». Frontiers in Behavioral Neuroscience 4, (2010), 1-20.
  • Peper, J.S., Hulshoff Pol, H.E., Crone, E.A., Van Honk, J. «Sex steroids and brain structure in pubertal boys and girls: a mini-review of neuroimaging studies» Neuroscience (2011)
  • Paus, T. «Mapping brain maturation and cognitive development during adolescence». Trends Cogn Sci 9, (2005), 60-68.
  • Cahill, L. «Why sex matters for neuroscience». Nat Rev Neurosci 7, (2006), 477- 484.
  • Kessler, R.C., Berglund, P., Demler, O., Jin, R., Merikangas, K.R., Walters, E.E. «Lifetime prevalence and age-of-onset distributions of SM-IV disorders in the National Comorbidity Survey Replication». Arch Gen Psychiatry 62, (2005), 593-50.
  • Rossow, J.E., Anderson, G.L., Prentice, R.L., LaCroix, A.Z., Kooperberg, C., Stefanick, M.L., Jackson, R.D., Beresford, S.A., Howard, B.V., Johnson, K.C., Kotchen, J.M., Ockene, J. «Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principle results from the Women’s Health Initiative randomized controlled trial». JAMA 288, (2002), 321-333.
  • Shumaker, S.A., Legault, C., Rapp, S.R., Thal, L., Wallace, R.B., et al. «Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women». The Women’s Health Initiative Memory Study: a randomized controlled trial». JAMA 289, (2003), 2651-2662.
  • Brass, L.M. «Estrogens and stroke: use of oral contraceptives and postmenopausal use of estrogen: current recommendations». Curr. Treat. Options Neurol. 6, (2004), 459-467.
  • Ravdin, P.M., Cronin, K.A., Howlader, N., Berg, C.D., Chlebowski, R.T., Feuer, E.J., Edwards, B.K., Berry, D.A. «The decrease in breast-cancer incidence in 2003 in the United States». N. Engl. J. Med. 356, (2007), 1670- 1674.
  • Key, T., Appleby, P., Barnes, I., Reeves, G. «Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies», J. Natl. Cancer Inst. 94, (2002), 606-616.
  • Canonico, M., Plu-Bureau, L.G.D., Scarabin, P.Y. Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: Systematic review and meta-analysis. BMJ, 336, (2008), 1227-1231.
  • Kumar, S., Lata, K., Mukhopadhyay, S., Mukherjee, T.K. «Role of estrogen receptors in prooxidative and anti-oxidative actions of estrogens: A perspective». Biochim. Biophys. Acta 1800, (2010), 1127-1135.
  • Österlund, M.K. «Underlying mechanisms mediating the antidepressant effects of estrogens». Biochim. Biophys. Acta 1800, (2010), 1136-1144.
  • Do Rego, J.L., Seong, J.Y., Burel, D., Le- Do Rego, J.L., Seong, J.Y., Burel, D., Leprince, J., Luu-The, V., Tsutsui, K., Tonon, M.C., Pelletier, G,. Vaudry, H. «Neurosteroid biosynthesis: enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides». Front. Neuroendocrinol. 30, (2009), 259-301.
  • Garcia-Segura, LM. «Aromatase in the brain: not just for reproduction any more». J Neuroendocrinol. 20, (2008), 705-12.
  • Azcoitia, I., Yague, J.G., García-Segura, L.M. «Estradiol synthesis within the human brain». Neuroscience 2011.
  • Boon, V.C., Chow J.D., Simpson, E.R. «The multiple roles of estrogens and the enzyme aromatase». Progress in Brain Research, 181, (2010), 209-232.
  • García-Segura, L.M., Melcangi, R.C. «Ster- García-Segura, L.M., Melcangi, R.C. «Ster- Segura, L.M., Melcangi, R.C. «Steroides and glial cell function». Glia 54, (2006), 485-498.
  • N-Wihlbäck AC, Sundström-Poromaa I, Bäckström T. «Action by and sensitivity to neuroactive steroids in menstrual cycle related CNS disorders». Psychopharmacology 186, (2006), 388-401.
  • Micevych, P., Sinchk, K. «Synthesis and Function of Hypothalamic Neuroprogesterone in Reproduction». Endocrinology 149, (2008), 2739-2742.
  • Channing, C.P., Hillensjo, T., Schaerf, F.W. «Hormonal control of oocyte meiosis, ovulation and luteinization in mammals». Clin Endocrinol Metab. 7, (1978), 601-24.
  • Hammes, S.R., Levin, E.R. «Extranuclear steroid receptors: nature and actions». Endocr Rev. 28, (2007), 726-41.
  • García-Segura, L.M., Lorenz, B., DonCarlos, L. «The role of glia in the hypothalamus: implications for gonadal steroide feedback and reproductive neuroendocrine output». Reproduction 135, (2008), 419-429.
  • Sellix, M.T., Egli, M, et al. «Ovarian steroid hormones nodulate circadian rhythms of nueroendocrine dopaminergic neuronal activity». Brain Reresearch 1005, (2004), 164-81.
  • Ter-Horst, G.J., Wichmann, R., et al. «Sex differences in stress response: focus in ovarian hormones». Physiol. Behav. 97, (2009), 239-249.
  • Baulieu, E.E., Schumacher, M., Koenig, H., Jung-Testas, I., Akwa, Y. «Progesterone as a neurosteroid: actions within the nervous system». Cell Mol. Neurobiol. 16(2), (1996), 143-54.
  • Zhu, Y., Bond, J., Thomas, P. «Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor». Proc Natl Acad Sci USA 100, (2003), 2237-42.
  • Kim, H.J., Casadesus, G. «Estrogen-mediated effects on cognition and synaptic plasticity: What do estrogen receptor knockout models tell us?» Biochimica et Biophysica Acta 1800, (2010). 1090-1093.
  • Petanceska, S.S., Nagy, V., Frail, D., Gandy, S. «Ovariectomy and 17β-estradiol modulate the levels of Alzheimer’s amyloid β peptides in brain». Neurology 54, (2000), 2212-2217.
  • Bi, R., Foy, M.R., Voulmba, R.M., Thompson, R.F., Baudry, M. «Cyclic changes in estrogen regulate synaptic plasticity through the MAP kinase pathway». Proc. Natl. Acad. Sci. USA 98, (2001), 13391-13395.
  • Flynn, J.M., Dimitrijevich, S.D., Younes, M., Skliris, G., Murphy, L.C., Cammarata, P.R. «Role of wild-type estrogen receptor-beta in mitochondrial cytoprotection of cultured normal male and female human lens epithelial cells» Am. J. Physiol. Endocrinol. Metab. 295, (2008), E637-E647.
  • McEwen, B.S. «Estrogen action throughout the brain». Recent Prog. Horm. Res. 57, (2002), 357-384.
  • Wolley, C.S. «Estrogen-mediated structural and functional synaptic plasticity in the female rat hippocampus». Horm. Behav. 34, (1998), 140-148.
  • Mukai, H., Tsurugizawa, T., Murakami, G., et al. «Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampalprincipal neurons». J. Neurochem. 100, (2007), 950-967.
  • Szymczak, S., et al. «Increased estrogen receptor beta expression correlates with decreased spine formation in the rat hippocampus». Hippocampus 16, (2006), 453-463.
  • Colby, J.B., Van Horn, J.D., Sowell, E.R. «Quantitative in vivo evidence for broad regional gradients in the timing of white matter maturation during adolescence». Neuroimage 54 (1), (2010), 25-31.
  • Bramen, J.E., Hranilovich, J.A., Dahl, R.E., Forbes E.E., Chen, J., Toga, A.W., Dinov, I.D., Worthman, C.M., Sowell, E.R. «Puberty influences medial temporal lobe and cortical gray matter maturation differently in boys than girls matched for sexual maturity». Cerebral Cortex 21(3), (2010), 636-646.
  • Giedd, J.N., Rapoport, J.L. «Structural MRI of pediatric brain development: what have we learned and where are we going?» Neuron 67, (2010), 728-734.
  • Luders E. «Los pliegues». Mente y Cerebro 9, (2004), 5.
  • Bramen, J.E., Hranilovich, J.A., Dahl, R.E., Forbes E.E., Chen, J., Toga, A.W., Dinov, I.D., Worthman, C.M., Sowell, E.R. «Puberty influences medial temporal lobe and cortical gray matter maturation differently in boys than girls matched for sexual maturity». Cerebral Cortex 21(3), (2010), 636-646.
  • Neufang, S., Specht, K., Hausmann, M., Güntürkün, O., Herpertz-Dahlmann, B., Fink, G.R., Konrad, K. «Sex Differences and the Impact of Steroid Hormones on the Developing Human Brain» Cerebral Cortex 19, (2009), 464-473.
  • Blakemore, S.J., Burnett, S., and Dahl, R.E. «The role of puberty in the developing adolescent brain». Human Brain Mapping 31, (2010), 926-933.
  • Silk, J.S., Siegle, G.J., Whalen, D.J., Ostap- Silk, J.S., Siegle, G.J., Whalen, D.J., Ostapenko, L.J., Ladouceur, C.D., Dahl, R.E. «Pubertal changes in emotional information processing: Pupillary, behavioral, and subjective evidence during emotional word identification». Development and Psychopathology 21, (2009), 7-26.
  • Steinberg, L., Graham, S., O’Brien, L., Wool- Steinberg, L., Graham, S., O’Brien, L., Woolard, J., Cauffman, E., Banich, M. «Age differences in future orientation and delay discounting». Child Development 80, (2009), 28-44.
  • Somerville, L.H., Casey, B.J. «Developmen- Somerville, L.H., Casey, B.J. «Developmental neurobiology of cognitive control and motivational systems». Current Opinion in Neurobiology 20, (2010), 236-24.
  • Naftolin, F., et al. «Estrogen-induced hyoithalamic synaptic plasticity and pituitary sensitization in the control pf the estrogen-induced gonadotrophin surge». Reprodud. Sci. 14, (2007), 101-116.
  • Sisk, C.L., Zehr, J.L. «Pubertal hormones organize the adolescent brain and behavior». Frontiers in Neuroendocrinology 26, (2005), 163-174.
  • Colby, J.B., Van Horn, J.D., E.R. Sowell Quantitative in vivo evidence for broad regional gradients in the timing of white matter maturation during adolescence. NeuroImagen 54, (2011) 25-31.
  • Schmithorst, V.J., Yuan, W. «White matter development during adolescence as shown by diffusion MRI». Brain and Cognition 72, (2010), 16-25.
  • Luna, B., Padmanabhan, A., y O’Hearn, K. «What has fMRI told us about the development of cognitive control through adolescence?» Brain and Cognition 72, (2010), 101-113.
  • Giedd, J.N., y Rapoport, J.L. «Structural MRI of pediatric brain development: what have we learned and where are we going?» Neuron 67, (2010), 728-734.
  • Casey, B.J., Duhoux, S., y Cohen, M.M. «Adolescence: What do transmission, transition, and translation have to do with it?» Neuron 6, (2010), 749-760.
  • Blakemore, S.J., Burnett, S., y Dahl, R.E. «The role of puberty in the developing adolescent brain». Human Brain Mapping 31, (2010), 926-933.
  • van Wingen, G., van Broekhoven, F., Ver- van Wingen, G., van Broekhoven, F., Verkes, R.J., Petersson, K.M., Bäckström, T., Buitelaar, J., Fernández, G.J. «How progesterone impairs memory for biologically salient stimuli in healthy young women». Neurosci. 27, (2007), 11416-23.
  • Cooke, B.M. «Steroid-dependent plasticity in the medial amygdala». Neuroscience 138, (2006), 997-1005.
  • Eichenbaum, H. «Hippocampus: cognitive processes and neural representations that underlie declarative memory». Neuron 44, (2004), 109-120.
  • McEwen, B.S., Milner, T.A. «Hippocampal formation: shedding light on the influence of sex and stress on the brain». Brain Res. Rev. 55, (2007), 343-355.
  • Shibuya, K., Takata, N., Hojo, Y., Furukawa, A., Yasumatsu, N., Kimoto, T., Enami, T., Suzuki, K,. Tanabe, N., Ishii, H., Mukai, H., Takahashi, T., Hattori, T.A., Kawato, S. «Hippocampal cytochrome P450s synthesize brain neurosteroids which areparacrine neuromodulators of synaptic signal transduction». Biochim. Biophys Acta 1619, (2003), 301-316.
  • Woolley, C.S. «Estrogen-mediated structural and functional synaptic plasticity inthe female rat hippocampus». Horm. Behav. 34, (1998), 140-148.
  • Morse, J.K., Scheff, S.W., DeKosky S.T. «Gonadal steroids influence axon sprouting in the hippocampal dentate gyrus: a sexually dimorphic response». Exp Neurol. 94, (1986), 649-658.
  • Clark, A.S., MacLusky, N.J., Goldman-Rakic, P.S. «Androgen binding and metabolism in the cerebral cortex of the developing rhesus monkey». Endocrinology 123, (1988), 932-940.
  • Sholl, S.A., Kim, K.L. «Estrogen receptors in the rhesus monkey brain during fetal development». Brain Res Dev Brain Res. 50, (1989), 189-196.
  • Galea, L.A., Uban, K.A., Epp, J.R., Brum- Galea, L.A., Uban, K.A., Epp, J.R., Brummelte, S., Barha, C.K., Wilson, W.L., Lieblich, S.E., Pawluski, J.L. «Endocrine regulation of cognition and neuroplasticity: our pursuit to unveil the complex interaction between hormones, the brain, and behaviour». Can. J. Exp. Psychol.62, (2008), 247-260.
  • Frick, K.M., Fernandez, S.M., Harburger, L.L. «A new approach to understanding the molecular mechanisms through which estrogens affect cognition». Biochimica et Biophysica Acta 1800, (2010), 1045-1055.
  • Cahill, L., Haier, R.J., White, N.S., Fallon, J., Kilpatrick, L., Lawrence, C., et. al. «Sex-related difference in amygdala activity during emotionally influenced memory storage». Neurobiol Learn Mem 75, (2001), 1-9.
  • Cahill, L. Desmond, J.E., Zhao, Z., Gabrieli, J.D.E. «Sex differences in the neural basis of emotional memories». Proc Natl Acad Sci USA 99, (2002), 10.789-10.794.
  • Cahill, L., Uncapher, M., Kilpatrick, L., Alkire, M.T., Turner, J. «Sex related hemispheric lateralization of amygdala function in emotionally influenced memory: an FMRI investigation». Learn Mem 11, (2004), 261-266.
  • Da Cunha, C., Roozendaal, B., Vazdarjano- Da Cunha, C., Roozendaal, B., Vazdarjanova, A., McGaugh, J.L. «Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats». Neurobiology of Learning and Memory 72, (1999), 1-7.
  • Mukai, H., Kimoto, K., Hojo, Y., Kawato, S. «Gen Murakami Shimpei Higo, Yusuke Hatanaka , Mari Ogiue-Ikeda Modulation of synaptic plasticity by brain estrogen in the hippocampus». Biochimica et Biophysica Acta 1800, (2010), 1030-1044.
  • Kretz, O., Fester, L., Wehrenberg, U., Zhou, L., Brauckmann, S., Zhao, S., Prange-Kiel, J., Naumann, T., Jarry, H., Frotscher, M., Rune, G.M. «Hippocampal synapses depend on hippocampal estrogen synthesis». J. Neurosci. 24, (2004), 5913-5921.
  • Woolley, C.S. «Estrogen-mediated structural and functional synaptic plasticity in the female rat hippocampus» Horm. Behav 34 (1998) 140-148.
  • Hojo, Y., Higo, S., Ishii, H., Ooishi, Y., Mukai, H., Murakami, G., Kominami, T., Kimoto, T., Honma, S., Poirier, D., Kawato, S. «Comparison between hippocampussynthesized and circulationderived sex steroids in the hippocampus». Endocrinology 150, (2009), 5106-5112.
  • Toran-Allerand, C.D., Singh, M., Setalo Jr., G. «Novel mechanisms of estrogen action in the brain: new players in an old story». Front Neuroendocrinol. 20, (1999), 97-121.
  • Weiland, N.G. «Estradiol selectively regulates agonist binding sites on the NmethylD-aspartate receptor complex in the CA1 region of the hippocampus». Endocrinology 131, (1992), 662-668.
  • Gazzaley, A.H., Weiland, N.G., McEwen, B.S., Morrison, J.H. «Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus». J. Neurosci. 16, (1996), 6830-6838.
  • Cyr, M., Ghribi, O., Di Paolo, T. «Regional and selective effects of oestradiol and progesterone on NMDA and AMPA receptors in the rat brain». J. Neuroendocrinol.12, (2000), 445-452.
  • Barha, C.K., Galea, L.A.M «Influence of different estrogens on neuroplasticity and cognition in the hippocampus». Biochimica et Biophysica Acta 1800, (2010), 1056-1067.
  • Hulshoff Pol, H.E., Cohen-Kettenis, P.T., Van Haren, N.E.M., Peper, J.S., Brans, R.G.H., Cahn, W., Schnack, H.G., Gooren, L.J.G., Kahn, R.S. «Changing your sex changes your brain: influences of testosterone and estrogen on adult human brain structure». European Journal of Endocrinology 155, (2006), 107-114.
  • Casey, B.J., Jones, R.M., Hare, T.A. «The Adolescent Brain». Annals of the New York Academy of Sciences 1124, (2008), 111-126.
  • Geier, C.F., Terwilliger, R., Teslovich, T., Velanova, K., Luna, B. «Immaturities in reward processing and its influence on inhibitory control in adolescence». Cerebral Cortex 20, (7), (2010), 1613-1629.
  • Spear, L.P. «The adolescent brain and agerelated behavioral manifestations». Neurosci Behav Rev 24, (2000), 417-463.
  • Hare, T.A., Tottenham, N., Galvan, A., Voss, H.U., Gary, H., Glover, G.H., Casey, B.J. «Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-no go task». Biological Psychiatry 63 (2008), 927-934.