From transcriptomics to proteomics: Unraveling biological knowledge via Machine Learning
- Mikel Hernáez Director
- Elizabeth Guruceaga Director/a
Universitat de defensa: Universidad de Navarra
Fecha de defensa: 20 de de desembre de 2022
- Antonio Pineda Lucena President
- Silvestre Vicent Cambra Secretari/ària
- Enrique Santamaría Martínez Vocal
- Ian Michael Traniello Vocal
- David Gómez-Cabrero López Vocal
Tipus: Tesi
Resum
We start by highlighting basic concepts of both molecular biology and machine learning. This overview focuses on the key ideas that are required to comprehend the rest of the work, and thus, it does not attempt at providing a comprehensive review. We start with the basis of DNA and RNA, the genetic building bricks, until the formation of the proteins, the final actors of the genetic machinery. We also explore state-of-the-art technologies to measure those processes along with their limitations. After introducing the basic biological concepts, we will discuss the basics of machine learning methodologies and some of the most important models used in recent years to solve many biological problems.