Interacción de nanoemulsiones con la barrera gastrointestinal

Abstract

The main objective of this work has been to understand the interactions between nanoemulsions and the gastrointestinal barriers. Therefore, nanoemulsions with different compositions have been proposed and their interactions with enzymes, mucus and intestinal cells have been evaluated. The results obtained indicated that the properties of the surface and the core of the nanoemulsions may modify the coating efficiency of the systems with the hydrophilic polymer Pluronic®F127. This determines their enzymatic lipid digestion rates and their diffusion through intestinal mucus. For that purpose, a novel screening approach has been proposed and a software, which offers robust data analysis, has been developed for its implementation. Active targeting of the nanoemulsions to the intestinal cells has been aimed by the interaction with the sodium-dependent ascorbic acid transporter that is expressed at the apical membrane of enterocytes. For that purpose, nanoemulsions were stabilized by ascorbyl-2,6-dipalmitate and were evaluated to determine their potential as oral drug delivery systems.