Smart cell-surface receptorsOn the 2012 Nobel Prize in Chemistry, awarded to Robert J. Lefkowitz and Brian K. Kobilka

  1. Rafael Franco 1
  2. María S. Aymerich 2
  1. 1 Universitat de Barcelona
    info

    Universitat de Barcelona

    Barcelona, España

    ROR https://ror.org/021018s57

  2. 2 Universidad de Navarra
    info

    Universidad de Navarra

    Pamplona, España

    ROR https://ror.org/02rxc7m23

Revista:
Contributions to Science

ISSN: 1575-6343

Año de publicación: 2013

Volumen: 9

Número: 1

Páginas: 25-32

Tipo: Artículo

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Otras publicaciones en: Contributions to Science

Resumen

The 2012 Nobel Prize in Chemistry recognized Professors Robert J. Lefkowtiz and Brian K. Kobilka for their work on β-adrenergic receptors, which have been the paradigm for understanding the mechanism of action of receptors coupled to heterotrimeric G proteins (GPCRs). In fact, the discovery of hundreds of members of this family of cell-surface receptors has provided a detailed understanding of how cells sense their environment. This brief article draws from the summary used by the Royal Swedish Academy of Sciences to support its choice of Lefkowitz and Kobilka for the 2012 award. It also considers some of the diverse applications of GPCRs.

Fuente de los datos: Dialnet