TGF-β made easy

  1. Garcia-Fernandez, N. 1
  2. Marco Molina, M.L. 1
  1. 1 Clínica Universitaria de Navarra
    info

    Clínica Universitaria de Navarra

    Pamplona, España

    ROR https://ror.org/03phm3r45

Zeitschrift:
The Open Urology & Nephrology Journal

ISSN: 1874-303X

Datum der Publikation: 2009

Ausgabe: 2

Nummer: 1

Seiten: 1-5

Art: Artikel

DOI: 10.2174/1874303X01002010001 GOOGLE SCHOLAR lock_openOpen Access editor

Andere Publikationen in: The Open Urology & Nephrology Journal

Zusammenfassung

Renal fibrosis is the final common pathway of several nephropathies including chronic allograft failure. Most chronic renal diseases result in tissue fibrosis, and this is independent of their initial cause. Tissue fibrosis is an accumulation of extracellular matrix, and in animal models of renal fibrosis, mRNA levels for profibrogenic cytokines such as transforming growth factor ß (TGFß) and extracellular matrix (ECM) molecular components are up regulated and they precede glomerulosclerosis and interstitial fibrosis. TGFß 1 plays a crucial role in renal fibrosis. In this review the main features of this important cytokine and existing previous therapeutic attempts to inhibit TGFß expression are briefly summarised.