Carcinomas renales con rasgos sarcomatoides y rabdoidesestudio clínico-patológico de 74 casos

  1. Queipo, F.J. 5
  2. Panizo, A. 1
  3. Sola, J.J. 2
  4. Beorlegui, C. 3
  5. Velis, J.M. 4
  6. Dolezal, P. 5
  7. Pardo-Mindán, J. 6
  1. 1 Complejo Hospitalario de Navarra, Pamplona.
  2. 2 Hospital San Pedro, Logroño.
  3. 3 Complejo Hospitalario de Navarra, Pamplona.T
  4. 4 Clínica Universidad de Navarra, Pamplona.
  5. 5 Hospital San Jorge, Huesca.
  6. 6 Universidad de Navarra
    info

    Universidad de Navarra

    Pamplona, España

    ROR https://ror.org/02rxc7m23

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Revista:
Anales del sistema sanitario de Navarra

ISSN: 1137-6627

Any de publicació: 2018

Volum: 41

Número: 2

Pàgines: 191-199

Tipus: Article

DOI: 10.23938/ASSN.0306 DIALNET GOOGLE SCHOLAR

Altres publicacions en: Anales del sistema sanitario de Navarra

Objectius de Desenvolupament Sostenible

Resum

Objetives. Our aim is to analyze and compare the clinico-pathological features in renal cell carcinomas (RCC) with sarcomatoid and rhaboid phenotype.Material and methods. We reviewed 1,258 RCC from consecutive patients with nephrectomy from 1988 to 2015, and those with ≥1% of sarcomatoid and/or rhabdoid change were selected. They were classified as sarcomatoid or rhabdoid according with the predominant morphology, considering the global frecuency of both phenotypes as dedifferentiated component. The following variables were collected: sex, age, symptoms and existence of metastases at diagnosis, parameters listed in the protocol of renal carcinoma of the American College of Pathologists, pattern of tumor growth, perineural invasion, percentage of both tumor necrosis and characteristics of the inflammatory infiltrate. They were described by mean/median or percentage, and compared with Student-t/Mann-Whitney U or χ2/Fisher).Results. We identified 45 RCC with sarcomatoid predominance (3,6%) and twenty-nine with rhabdoid predominance (2,3%); the first one showed a higher dedifferentiated component and perineural invasion (27.5 vs. 13.5%, p=0.003 and 28.9 vs. 3.4%, p=0.006, respectively), while the former showed a higher proportion of neutrophilic inflammation (44.8 vs. 22.2%, p=0.04) and arose more frequently over high grade RCC (55.9 vs. 90.5%, p<0,001).  Conclusions. There was overlapping of the clinico-pathological features of RCC with sarcomatoid and rhaboid phenotype, except for dedifferentiated component, perineural invasion and neutrophilic inflammation. This close relationship could be explained by a common underlying mechanism, the epithelial-mesenchymal transition, with a double morphological expression that, if confirmed, could lead to selecting patients that would benefit from follow-up or treatment depending on their molecular characteristics.

Referències bibliogràfiques

  • SIEGEL RL, MILLER KD, JEMAL A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65: 5-29.
  • SRIGLEY JR, DELAHUNT B, EBLE JN, EGEVAD L, EPSTEIN JI, GRIGNON D et al. The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia. Am J Surg Pathol 2013; 37: 1469-1489.
  • DELAHUNT B, CHEVILLE J, MARTIGNONI G, HUMPHREY P, MAGI-GALLUZZI C, MCKENNEY J et al. Members of the ISUP Renal Tumor Panel. The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol 2013; 37: 1490-1504.
  • DE PERALTA-VENTURINA M, MOCH H, AMIN M, TAMBOLI P, HAILEMARIAM S, MIHATSCH M et al. Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. Am J Surg Pathol 2001; 25: 275-284.
  • GÖKDEN N, NAPPI O, SWANSON PE, PFEIFER JD, VOLLMER RT, WICK MR et al. Renal cell carcinoma with rhabdoid features. Am J Surg Pathol 2000; 24: 1329-1338.
  • ZHANG BY, CHEVILLE JC, THOMPSON RH, LOHSE CM, BOORJIAN SA, LEIBOVICH BC et al. Impact of rhabdoid differentiation on prognosis for patients with grade 4 renal cell carcinoma. Eur Urol 2015; 68: 5-7.
  • PRZYBYCIN CG, MCKENNEY JK, REYNOLDS JP, CAMPBELL S, ZHOU M, KARAFA MT et al. Rhabdoid differentiation is associated with aggressive behavior in renal cell carcinoma: a clinicopathologic analysis of 76 cases with clinical follow-up. Am J Surg Pathol 2014; 38: 1260-1265.
  • CHAPMAN-FREDRICKS JR, HERRERA L, BRACHO J, GOMEZ-FERNANDEZ C, LEVEILLEE R, REY L et al. Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. Ann Diagn Pathol 2011; 15: 333-337.
  • CHEVILLE JC, LOHSE CM, ZINCKE H, WEAVER AL, LEIBOVICH BC, FRANK I et al. Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. Am J Surg Pathol 2004; 28: 435-441.
  • SRIGLEY JR, AMIN MB, DELAHUNT B, CAMPBELL SC, CHANG A, GRIGNON DJ et al. Protocol for the examination of specimens from patients with invasive carcinoma of renal tubular origin. Arch Pathol Lab Med 2010; 134: e25-e30.
  • EDGE SB, BYRD DR, COMPTON CC, FRITZ AG, GREENE FL, TROTTI A. AJCC cancer staging manual. 7th ed: New York: Springer, 2010.
  • TRPKOV K, GRIGNON DJ, BONSIB SM, AMIN MB, BILLIS A, LOPEZ-BELTRAN A et al. Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. Am J Surg Pathol 2013; 37: 1505-1517.
  • PARK JY, LEE JL, BAEK S, EO SH, GO H, RO JY et al. Sarcomatoid features, necrosis, and grade are prognostic factors in metastatic clear cell renal cell carcinoma with vascular endothelial growth factor-targeted therapy. Hum Pathol 2014; 45: 1437-1444.
  • FUKATSU A, TSUZUKI T, SASSA N, NISHIKIMI T, KIMURA T, MAJIMA T et al. Growth pattern, an important pathologic prognostic parameter for clear cell renal cell carcinoma. Am J Clin Pathol 2013; 140: 500-505.
  • BEUSELINCK B, LERUT E, WOLTER P, DUMEZ H, BERKERS J, VAN POPPEL H et al. Sarcomatoid dedifferentiation in metastatic clear cell renal cell carcinoma and outcome on treatment with anti–vascular endothelial growth factor receptor tyrosine kinase inhibitors: A retrospective analysis. Clin Genitourin Cancer 2014; 12: e205-e214.
  • GOLSHAYAN AR, GEORGE S, HENG DY, ELSON P, WOOD LS, MEKHAIL TM et al. Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. J Clin Oncol 2009; 27: 235-241.
  • KIM T, ZARGAR-SHOSHTARI K, DHILLON J, LIN H-Y, YUE B, FISHMAN M et al. Using percentage of sarcomatoid differentiation as a prognostic factor in renal cell carcinoma. Clin Genitourin Cancer 2015; 13: 225-230.
  • BROOKMAN-MAY S, MAY M, SHARIAT SF, ZIGEUNER R, CHROMECKI T, CINDOLO L et al. Prognostic effect of sarcomatoid dedifferentiation in patients with surgically treated renal cell carcinoma: a matched-pair analysis. Clin Genitourin Cancer 2013; 11: 465-470.
  • TERRONE C, CRACCO C, GUERCIO S, BOLLITO E, POGGIO M, SCOFFONE C et al. Prognostic value of the involvement of the urinary collecting system in renal cell carcinoma. Eur Urol 2004; 46: 472-476.
  • AALTOMAA S, LIPPONEN P, KÄRJÄ V, LUNDSTEDT S, LAPPI J, KOSMA VM. The expression and prognostic value of α-, β-and γ-catenins in renal cell carcinoma. Anticancer Res 2004; 24: 2407-2414.
  • KUROIWA K, KONOMOTO T, KUMAZAWA J, NAITO S, TSUNEYOSHI M. Cell proliferative activity and expression of cell-cell adhesion factors (E-cadherin, α-, β-, and γ-catenin, and p120) in sarcomatoid renal cell carcinoma. J Surg Oncol 2001; 77: 123-131.
  • YAN Y, LIU L, ZHOU J, LI L, LI Y, CHEN M et al. Clinicopathologic characteristics and prognostic factors of sarcomatoid renal cell carcinoma. J Cancer Res Clin Oncol 2015; 141: 345-352.
  • HUMPHREY PA. Renal cell carcinoma with rhabdoid features. J Urol 2011; 186: 675-676.
  • ZHANG BY, THOMPSON RH, LOHSE CM, LEIBOVICH BC, BOORJIAN SA, CHEVILLE JC et al. A novel prognostic model for patients with sarcomatoid renal cell carcinoma. BJU Int 2015; 115: 405-411.
  • JENSEN HK, DONSKOV F, MARCUSSEN N, NORDSMARK M, LUNDBECK F, VON DER MAASE H. Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma. J Clin Oncol 2009; 27: 4709-4717.
  • LEROY X, ZINI L, BUOB D, BALLEREAU C. Renal cell carcinoma with rhabdoid features: an aggressive neoplasm with overexpression of p53. Arch Pathol Lab Med 2007; 131: 102-106.
  • HE H, MAGI-GALLUZZI C. Epithelial-to-mesenchymal transition in renal neoplasms. Adv Anat Pathol 2014; 21: 174-180.
  • DELAHUNT B. Sarcomatoid renal carcinoma: the final common dedifferentiation pathway of renal epithelial malignancies. Pathology 1999; 31: 185-190.
  • SHUCH B, BRATSLAVSKY G, SHIH J, VOURGANTI S, FINLEY D, CASTOR B et al. Impact of pathological tumour characteristics in patients with sarcomatoid renal cell carcinoma. BJU Int 2012; 109: 1600-1606.
Fuente de los datos: Dialnet