Fibroblast growth factors 19 and 21 in acute liver damage

  1. Shan, Zhao 3
  2. Alvarez-Sola, Gloria 12
  3. Uriarte, Iker 12
  4. Arechederra, María 12
  5. Fernández-Barrena, Maite G. 12
  6. Berasain, Carmen 124
  7. Ju, Cynthia 3
  8. Avila, Matías A. 124
  1. 1 Universidad de Navarra
    info

    Universidad de Navarra

    Pamplona, España

    ROR https://ror.org/02rxc7m23

  2. 2 Instituto de Salud Carlos III
    info

    Instituto de Salud Carlos III

    Madrid, España

    ROR https://ror.org/00ca2c886

  3. 3 University of Texas Health Science Center at Houston
    info

    University of Texas Health Science Center at Houston

    Houston, Estados Unidos

    ROR https://ror.org/03gds6c39

  4. 4 Instituto de Investigación Sanitaria de Navarra
    info

    Instituto de Investigación Sanitaria de Navarra

    Pamplona, España

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Revista:
Annals of Translational Medicine

ISSN: 2305-5839,  2305-5847

Ano de publicación: 2018

Volume: 6

Número: 12

Páxinas: 257

Tipo: Revisión

DOI: 10.21037/ATM.2018.05.26 WoS: WOS:000437527200016 GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Annals of Translational Medicine

Resumo

Currently there are very few pharmacological options available to treat acute liver injury. Because its natural exposure to noxious stimuli the liver has developed a strong endogenous hepatoprotective capacity. Indeed, experimental evidence exposed a variety of endogenous hepatic and systemic responses naturally activated to protect the hepatic parenchyma and to foster liver regeneration, therefore preserving individual's survival. The fibroblast growth factor (FGF) family encompasses a range of polypeptides with important effects on cellular differentiation, growth survival and metabolic regulation in adult organisms. Among these FGFs, FGF19 and FGF21 are endocrine hormones that profoundly influence systemic metabolism but also exert important hepatoprotective activities. In this review, we revisit the biology of these factors and highlight their potential application for the clinical management of acute liver injury.