Severe colon ischemia in patients with severe coronavirus-19 (COVID-19)
- Almeida Vargas, Ana 1
- Valentí, Víctor 123
- Sánchez Justicia, Carlos 1
- Martínez Regueira, Fernando 1
- Martí Cruchaga, Pablo 1
- Luján Colás, Juan 1
- Aliseda Jover, Daniel 1
- Esteban Gordillo, Sara 1
- Cienfuegos, Javier A. 123
- Rotellar Sastre, Fernando 1
-
1
Clínica Universitaria de Navarra
info
-
2
Instituto de Investigación Sanitaria de Navarra
info
Instituto de Investigación Sanitaria de Navarra
Pamplona, España
-
3
Instituto de Salud Carlos III
info
ISSN: 1130-0108
Argitalpen urtea: 2020
Alea: 112
Zenbakia: 10
Orrialdeak: 784 - 787
Mota: Artikulua
Beste argitalpen batzuk: Revista Española de Enfermedades Digestivas
Laburpena
COVID-19 is associated with severe coagulopathy. We present three cases of colonic ischemia that can be attributed to the hypercoagulable state related with SARS-CoV2 and disseminated intravascular coagulation. Three males aged 76, 68 and 56 with respiratory distress presented episodes of rectal bleeding, abdominal distension and signs of peritoneal irritation. Endoscopy (case 1) and computed tomography angiography revealed colonic ischemia. One patient (case 2) in which a computed tomography (CT) scan showed perforation of the gangrenous cecum underwent surgery. D-dimer levels were markedly increased (2,170, 2,100 and 7,360 ng/ml) in all three patients. All three patients died shortly after diagnosis.
Erreferentzia bibliografikoak
- 10.1053/j.gastro.2020.04.017
- 2. Pan L, Mu M, Yang P, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am. J. Gastroenterol. 2020: 115(5):766-773.1. Available at: http://www.ncbi.nlm.nih.gov/pubmed/32287140..
- 3. Crespo J, Iglesias-garcia J., Hinojosa del Val J. et al. Covid-19 y aparato digestivo: protección y manejo en la pandemia por SARS-CoV-2. Rev. Esp. Enferm Dig. 2020;112 (5):389-396.
- 4. Agarwal A, Chen A, Ravindran N, et al. Gastrointestinal and Liver Manifestations of COVID-19. J. Clin. Exp. Hepatol. 2020;10(3):263-265.
- 10.1016/j.jceh.2020.03.001
- 5. Xie C, Jiang L, Huang G, et al. Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests. Int. J. Infect. Dis. 2020;93:264�267.
- 6. Monkemüller K, Fry L C, Rickers S. Covid-19, Coronavirus, SARS-CoV-2 and the small bowell. Rev Esp Enferm Dig 2020;112(5):383-388.
- 7. Li H, Liu L, Zhang D, et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet (London, England) 2020;10(3):263-265.
- 10.1016/j.jceh.2020.03.001
- 10.1016/j.cell.2020.02.052
- 10.1016/S0140-6736(20)30566-3
- 10. Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet (London, England) 2020;395:1417�1418. Available at: http://www.ncbi.nlm.nih.gov/pubmed/32325026.
- 11. Ding Y, He L, Zhang Q, et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J. Pathol. 2004;203:622�30. Available at: http://www.ncbi.nlm.nih.gov/pubmed/15141376..
- 10.1111/jth.14817
- 10.1111/jth.14817
- 13. Zhang L, Feng X, Zhang D, et al. Deep Vein Thrombosis in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19) in Wuhan, China: Prevalence, Risk Factors, and Outcome. Circulation 2020.120.046702. Available at: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.046702..
- 10.1056/NEJMc2007575 Available at: http://www.ncbi.nlm.nih.gov/pubmed/32268022
- 10.1016/j.jacc.2020.04.031. Available at: http://www.ncbi.nlm.nih.gov/pubmed/32311448