Genetics of Obstructive Sleep Apnea

  1. Patiño-García, Ana 1
  1. 1 Clínica Universitaria de Navarra
    info

    Clínica Universitaria de Navarra

    Pamplona, España

    ROR https://ror.org/03phm3r45

Liburua:
Obstructive Sleep Apnea

Argitaletxea: Springer

ISBN: 978-3-031-35224-9,  978-3-031-35225-6

Argitalpen urtea: 2023

Orrialdeak: 479-486

Mota: Liburuko kapitulua

DOI: 10.1007/978-3-031-35225-6_28 GOOGLE SCHOLAR lock_openSarbide irekia editor

Laburpena

Obstructive sleep apnea (OSA) is a highly prevalent disease with severe effects on health. Nevertheless, nowadays, we lack biomarkers for OSA diagnosis that provide information about treatment outcomes, complications, and comorbidities. OSA is a very complex trait from the clinical and genetic points of view. It is conditioned by a plethora of low-risk genes, their interactions, and their interplay with a network of environmental factors. This chapter aims to be a review of the different genetic biomarkers of OSA as well as the different types of study designs for their identification, namely linkage analyses, genome-wide association studies (GWAS), candidate gene association studies, and whole-genome or -exome sequencing by next-generation sequencing (NGS).

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