Juan José
Lasarte Sagastibelza
Catedrático de Universidad
Publicaciones en las que colabora con Juan José Lasarte Sagastibelza (25)
2024
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Tethered IL15-IL15Rα augments antitumor activity of CD19 CAR-T cells but displays long-term toxicity in an immunocompetent lymphoma mouse model
Journal for immunotherapy of cancer, Vol. 12, Núm. 7
2023
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Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
Nature Medicine, Vol. 29, Núm. 3, pp. 632-645
2022
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CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome
Science Advances, Vol. 8, Núm. 39
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Gemcitabine-mediated depletion of immunosuppressive dendritic cells enhances the efficacy of therapeutic vaccination
Frontiers in Immunology, Vol. 13
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TCR-induced FOXP3 expression by CD8+ T cells impairs their anti-tumor activity
Cancer Letters, Vol. 528, pp. 45-58
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Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells
Journal for ImmunoTherapy of Cancer, Vol. 10, Núm. 8
2020
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Id1 and pd-1 combined blockade impairs tumor growth and survival of KRAS-mutant lung cancer by stimulating PD-l1 expression and tumor infiltrating CD8+ T cells
Cancers, Vol. 12, Núm. 11, pp. 1-22
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Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade
Nature cancer, Vol. 1, Núm. 1, pp. 75-85
2019
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PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas
Blood, Vol. 133, Núm. 22, pp. 2401-2412
2017
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Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies
Nature Communications, Vol. 8
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Expansion of tumor-infiltrating CD8+ T cells expressing PD-1 improves the efficacy of adoptive T-cell therapy
Cancer Research, Vol. 77, Núm. 13, pp. 3672-3684
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IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination
Oncotarget, Vol. 8, Núm. 2, pp. 2659-2671
2016
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Gene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance
Journal of Medical Virology, Vol. 88, Núm. 5, pp. 843-851
2015
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Clinical testing of a dendritic cell targeted therapeutic vaccine in patients with chronic hepatitis C virus infection
Molecular Therapy - Methods and Clinical Development, Vol. 2, pp. 15006
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Engineering Anti-myeloma Responses Using Affinity-Enhanced TCR-Engineered T Cells
Cancer Cell
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Immune monitoring of immunosuppression withdrawal of liver transplant recipients
Transplant Immunology, Vol. 33, Núm. 2, pp. 110-116
2013
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Helper cell-independent antitumor activity of potent CD8+ T cell epitope peptide vaccines is dependent upon CD40L
OncoImmunology, Vol. 2, Núm. 12, pp. 1-11
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Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance
Liver Transplantation, Vol. 19, Núm. 9, pp. 937-944
2011
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Enhanced T cell responses against hepatitis C virus by ex vivo targeting of adenoviral particles to dendritic cells
Hepatology, Vol. 54, Núm. 1, pp. 28-37
2008
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Combined immunization with adjuvant molecules poly(I:C) and anti-CD40 plus a tumor antigen has potent prophylactic and therapeutic antitumor effects
Cancer Immunology, Immunotherapy, Vol. 57, Núm. 1, pp. 19-29