Miguel
Fernández de Sanmamed Gutiérrez
Consultor Médico
Publicaciones en las que colabora con Miguel Fernández de Sanmamed Gutiérrez (18)
2024
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Short-term cultured tumor fragments to study immunotherapy combinations based on CD137 (4-1BB) agonism
OncoImmunology, Vol. 13, Núm. 1
2023
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Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity
Cancer immunology research, Vol. 11, Núm. 2, pp. 184-198
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mRNAs encoding IL-12 and a decoy-resistant variant of IL-18 synergize to engineer T cells for efficacious intratumoral adoptive immunotherapy
Cell Reports Medicine, Vol. 4, Núm. 3
2022
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A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα and IL-1β
Cancer Discovery, Vol. 12, Núm. 9, pp. 2140-2157
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Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
Journal for immunotherapy of cancer, Vol. 10, Núm. 3
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Three-dimensional colon cancer organoids model the response to CEA-CD3 T-cell engagers
Theranostics, Vol. 12, Núm. 3, pp. 1373-1387
2021
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Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Núm. 26
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CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation
Nature Communications, Vol. 12, Núm. 1
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Differential Interleukin-8 thresholds for chemotaxis and netosis in human neutrophils
European Journal of Immunology, Vol. 51, Núm. 9, pp. 2274-2280
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Heterogenous presence of neutrophil extracellular traps in human solid tumours is partially dependent on IL-8
Journal of Pathology, Vol. 255, Núm. 2, pp. 190-201
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IL8, neutrophils, and NETs in a collusion against cancer immunity and immunotherapy
Clinical Cancer Research, Vol. 27, Núm. 9, pp. 2383-2393
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Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy
Journal for ImmunoTherapy of Cancer, Vol. 9, Núm. 11
2020
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CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity
Immunity, Vol. 52, Núm. 5, pp. 856-871.e8
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Human CD8 T cells are susceptible to TNF-mediated activation-induced cell death
Theranostics, Vol. 10, Núm. 10, pp. 4481-4489
2019
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Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells
Cancer cell, Vol. 36, Núm. 6, pp. 613-629
2017
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Interleukin-8 in cancer pathogenesis, treatment and follow-up
Cancer Treatment Reviews, Vol. 60, pp. 24-31
2016
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Tumor-Produced Interleukin-8 Attracts human myeloid-derived suppressor cells and elicits extrusion of Neutrophil Extracellular Traps (NETs)
Clinical Cancer Research, Vol. 22, Núm. 15, pp. 3924-3936
2012
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The HIF-1α hypoxia response in tumor-infi ltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy
Cancer Discovery, Vol. 2, Núm. 7, pp. 608-623