Publicaciones en colaboración con investigadores/as de Universidad de la República (35)

2013

  1. Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents

    European Journal of Medicinal Chemistry, Vol. 66, pp. 324-334

  2. Phenazine N,N′-dioxide scaffold as selective hypoxic cytotoxin pharmacophore. Structural modifications looking for further DNA topoisomerase II-inhibition activity

    MedChemComm, Vol. 4, Núm. 3, pp. 595-607

2011

  1. 3-trifluoromethylquinoxaline N, N′-dioxides as anti-Trypanosomatid agents. Identification of optimal anti- T. cruzi agents and mechanism of action studies

    Journal of Medicinal Chemistry, Vol. 54, Núm. 10, pp. 3624-3636

  2. Genetic toxicology and preliminary in vivo studies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents

    Drug and Chemical Toxicology, Vol. 34, Núm. 3, pp. 285-293

2010

  1. Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2- carbonitrile di-N-oxides

    Bioorganic and Medicinal Chemistry Letters, Vol. 20, Núm. 16, pp. 4831-4835

  2. Design of novel iron compounds as potential therapeutic agents against tuberculosis

    Journal of Inorganic Biochemistry, Vol. 104, Núm. 11, pp. 1164-1170

  3. Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 14, pp. 5391-5399

  4. Structural modifications on the phenazine N,N′-dioxide-scaffold looking for new selective hypoxic cytotoxins

    European Journal of Medicinal Chemistry, Vol. 45, Núm. 11, pp. 5362-5369

  5. Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 12, pp. 4433-4440

2009

  1. Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs

    Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 4, pp. 1623-1629

  2. Cytotoxic, mutagenic and genotoxic effects of new anti-T. cruzi 5-phenylethenylbenzofuroxans. Contribution of phase I metabolites on the mutagenicity induction

    Toxicology Letters, Vol. 190, Núm. 2, pp. 140-149

  3. Heterocyclic-2-carboxylic Acid (3-Cyano-1,4-di-N-oxidequinoxalin-2-yl)amide Derivatives as Hits for the Development of Neglected Disease Drugs

    Molecules, Vol. 14, Núm. 6, pp. 2256-2272

  4. Research of new mixed-chelate copper complexes with quinoxaline N1,N4,-dioxide derivatives and alanine as ligands, potential antimycobacterial agents

    Journal of the Argentine Chemical Society, Vol. 97, Núm. 1, pp. 80-89

  5. Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates

    Bioorganic and Medicinal Chemistry, Vol. 17, Núm. 2, pp. 641-652

2008

  1. New copper-based complexes with quinoxaline N1,N4-dioxide derivatives, potential antitumoral agents

    Journal of Inorganic Biochemistry, Vol. 102, Núm. 1, pp. 119-126

2007

  1. Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure-activity relationships

    Bioorganic and Medicinal Chemistry, Vol. 15, Núm. 10, pp. 3356-3367

2006

  1. Design and evaluation of "3 + 1" mixed ligand oxorhenium and oxotechnetium complexes bearing a nitroaromatic group with potential application in nuclear medicine oncology

    European Journal of Medicinal Chemistry, Vol. 41, Núm. 10, pp. 1144-1152

  2. Improving anti-trypanosomal activity of 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives by complexation with vanadium

    Bioorganic and Medicinal Chemistry, Vol. 14, Núm. 16, pp. 5503-5509

  3. Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies

    Bioorganic and Medicinal Chemistry, Vol. 14, Núm. 10, pp. 3467-3480

  4. Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies

    Medicinal Chemistry, Vol. 2, Núm. 5, pp. 511-521