Julen
Oyarzabal Santamarina
Investigador hasta 2018
Josune
Orbe Lopategui
Profesional Investigadora
Publicaciones en las que colabora con Josune Orbe Lopategui (6)
2022
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CM-352 Efficacy in a Mouse Model of Anticoagulant-Associated Intracranial Hemorrhage
Thrombosis and Haemostasis, Vol. 122, Núm. 8, pp. 1314-1325
2019
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Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease
Scientific Reports, Vol. 9, Núm. 1
2018
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Phenotypic Screening to Discover Novel Chemical Series as Efficient Antihemorrhagic Agents
ACS Medicinal Chemistry Letters, Vol. 9, Núm. 5, pp. 428-433
2017
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CM352 reduces brain damage and improves functional recovery in a rat model of intracerebral hemorrhage
Journal of the American Heart Association, Vol. 6, Núm. 6
2015
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Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: From hit identification to an optimized lead
Journal of Medicinal Chemistry, Vol. 58, Núm. 5, pp. 2465-2488
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Discovery and Safety Profiling of a Potent Preclinical Candidate, (4-[4-[[(3 R)-3-(Hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]- N -methylbenzamide) (CM-352), for the Prevention and Treatment of Hemorrhage
Journal of Medicinal Chemistry, Vol. 58, Núm. 7, pp. 2941-2957