Ana María
García Osta
Profesional Investigadora
María del Mar
Cuadrado Tejedor
Catedrática de Universidad
Publicaciones en las que colabora con María del Mar Cuadrado Tejedor (43)
2024
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Characterization of brain transduction capability of a BBB-penetrant AAV vector in mice, rats and macaques reveals differences in expression profiles
Gene Therapy, Vol. 31, Núm. 9-10, pp. 455-466
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Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice
Neural Regeneration Research, Vol. 19, Núm. 9, pp. 2068-2074
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The immune system: uncharted pathways between senses and the brain
Neural Regeneration Research, Vol. 19, Núm. 6, pp. 1173-1174
2023
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Docosahexaenoic Acid Ameliorates Contextual Fear Memory Deficits in the Tg2576 Alzheimer’s Disease Mouse Model: Cellular and Molecular Correlates
Pharmaceutics, Vol. 15, Núm. 1
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Improvement of cognitive function in wild-type and Alzheimer´s disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells
Frontiers in Immunology, Vol. 14
2021
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Amyloid-driven tau accumulation on mitochondria potentially leads to cognitive deterioration in alzheimer’s disease
International Journal of Molecular Sciences, Vol. 22, Núm. 21
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Identifying the main functional pathways associated with cognitive resilience to alzheimer’s disease
International Journal of Molecular Sciences, Vol. 22, Núm. 17
2020
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GLUT12 Expression in Brain of Mouse Models of Alzheimer’s Disease
Molecular Neurobiology, Vol. 57, Núm. 2, pp. 798-805
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Linking histone deacetylases and phosphodiesterase 5 in novel treatments for Alzheimer’s disease
Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 (Elsevier), pp. 213-226
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PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment
Progress in Neurobiology, Vol. 191
2019
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Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class i Histone Deacetylase Selective Inhibitors
ACS Chemical Neuroscience, Vol. 10, Núm. 3, pp. 1765-1782
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Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles
ACS Chemical Neuroscience, Vol. 10, Núm. 9, pp. 4076-4101
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Taking advantage of the selectivity of histone deacetylases and phosphodiesterase inhibitors to design better therapeutic strategies to treat Alzheimer's disease
Frontiers in Aging Neuroscience, Vol. 11, Núm. JUN
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Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy
Molecular Therapy - Nucleic Acids, Vol. 16, pp. 26-37
2018
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Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 150, pp. 506-524
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Immunomodulatory properties of carvone inhalation and its effects on contextual fear memory in mice
Frontiers in Immunology, Vol. 9, Núm. JAN
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Impact of Neurodegenerative Diseases on Drug Binding to Brain Tissues: From Animal Models to Human Samples
Neurotherapeutics, Vol. 15, Núm. 3, pp. 742-750
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The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma
Neuro-Oncology, Vol. 20, Núm. 7, pp. 930-941
2017
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A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice
Neuropsychopharmacology, Vol. 42, Núm. 2, pp. 524-539
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Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer’s Disease
ACS Chemical Neuroscience, Vol. 8, Núm. 3, pp. 638-661