Jesús
San Miguel Izquierdo
Consultor Investigador
María Mercedes
Garayoa Berrueta
Publicaciones en las que colabora con María Mercedes Garayoa Berrueta (19)
2017
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Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair
Journal of Hematology and Oncology, Vol. 10, Núm. 1
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Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bor tezomib and dexamethasone
Haematologica, Vol. 102, Núm. 1, pp. 168-175
2016
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Effects of IL-8 Up-Regulation on Cell Survival and Osteoclastogenesis in Multiple Myeloma
American Journal of Pathology, Vol. 186, Núm. 8, pp. 2171-2182
2015
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In vivo murine model of acquired resistance in myeloma reveals differential mechanisms for lenalidomide and pomalidomide in combination with dexamethasone
Leukemia, Vol. 29, Núm. 3, pp. 705-714
2014
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Phenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines
PLoS ONE, Vol. 9, Núm. 3
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Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: Implications in myeloma progression and myeloma bone disease
Oncotarget, Vol. 5, Núm. 18, pp. 8284-8305
2013
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Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile
Blood, Vol. 122, Núm. 22, pp. 3591-3598
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RAF265, a dual BRAF and VEGFR2 inhibitor, prevents osteoclast formation and resorption. Therapeutic implications
Investigational New Drugs, Vol. 31, Núm. 1, pp. 200-205
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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects
Leukemia, Vol. 27, Núm. 2, pp. 430-440
2012
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CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype
Haematologica, Vol. 97, Núm. 7, pp. 1110-1114
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Dasatinib as a bone-modifying agent: Anabolic and anti-resorptive effects
PLoS ONE, Vol. 7, Núm. 4
2011
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Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response
Haematologica, Vol. 96, Núm. 5, pp. 687-695
2010
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In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma
Haematologica, Vol. 95, Núm. 5, pp. 794-803
2009
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Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors
Leukemia, Vol. 23, Núm. 8, pp. 1515-1527
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The synergy of panobinostat plus doxorubicin in acute myeloid leukemia suggests a role for HDAC inhibitors in the control of DNA repair
Leukemia, Vol. 23, Núm. 12, pp. 2265-2274
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Zalypsis: A novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks
Blood, Vol. 113, Núm. 16, pp. 3781-3791
2008
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Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo
Cancer Research, Vol. 68, Núm. 13, pp. 5216-5225
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The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype
Haematologica, Vol. 93, Núm. 1, pp. 57-66
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The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells
British Journal of Haematology, Vol. 141, Núm. 4, pp. 470-482