Publicaciones en colaboración con investigadores/as de Universidad de la República (27)

2013

  1. Phenazine N,N′-dioxide scaffold as selective hypoxic cytotoxin pharmacophore. Structural modifications looking for further DNA topoisomerase II-inhibition activity

    MedChemComm, Vol. 4, Núm. 3, pp. 595-607

2011

  1. 3-trifluoromethylquinoxaline N, N′-dioxides as anti-Trypanosomatid agents. Identification of optimal anti- T. cruzi agents and mechanism of action studies

    Journal of Medicinal Chemistry, Vol. 54, Núm. 10, pp. 3624-3636

  2. Genetic toxicology and preliminary in vivo studies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents

    Drug and Chemical Toxicology, Vol. 34, Núm. 3, pp. 285-293

2010

  1. Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 14, pp. 5391-5399

  2. Structural modifications on the phenazine N,N′-dioxide-scaffold looking for new selective hypoxic cytotoxins

    European Journal of Medicinal Chemistry, Vol. 45, Núm. 11, pp. 5362-5369

  3. Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 12, pp. 4433-4440

2009

  1. Cytotoxic, mutagenic and genotoxic effects of new anti-T. cruzi 5-phenylethenylbenzofuroxans. Contribution of phase I metabolites on the mutagenicity induction

    Toxicology Letters, Vol. 190, Núm. 2, pp. 140-149

2008

  1. Antitumoral effect of phenazine N5,N10-dioxide derivatives on Caco-2 cells

    Chemical Research in Toxicology, Vol. 21, Núm. 8, pp. 1578-1585

  2. New copper-based complexes with quinoxaline N1,N4-dioxide derivatives, potential antitumoral agents

    Journal of Inorganic Biochemistry, Vol. 102, Núm. 1, pp. 119-126

2007

  1. Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure-activity relationships

    Bioorganic and Medicinal Chemistry, Vol. 15, Núm. 10, pp. 3356-3367

2006

  1. Design and evaluation of "3 + 1" mixed ligand oxorhenium and oxotechnetium complexes bearing a nitroaromatic group with potential application in nuclear medicine oncology

    European Journal of Medicinal Chemistry, Vol. 41, Núm. 10, pp. 1144-1152

  2. Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies

    Bioorganic and Medicinal Chemistry, Vol. 14, Núm. 10, pp. 3467-3480

  3. Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies

    Medicinal Chemistry, Vol. 2, Núm. 5, pp. 511-521

  4. Selective hypoxia-cytotoxins based on vanadyl complexes with 3-aminoquinoxaline-2-carbonitrile-N1,N4-dioxide derivatives

    Journal of Inorganic Biochemistry, Vol. 100, Núm. 8, pp. 1358-1367

2005

  1. Novel Cu(II) quinoxaline N1,N4-dioxide complexes as selective hypoxic cytotoxins

    European Journal of Medicinal Chemistry, Vol. 40, Núm. 5, pp. 473-480

  2. Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins

    Journal of Medicinal Chemistry, Vol. 48, Núm. 1, pp. 21-23

  3. Synthesis and biological properties of new 5-nitroindazole derivatives

    Bioorganic and Medicinal Chemistry, Vol. 13, Núm. 9, pp. 3197-3207

  4. Vanadium(V) complexes with salicylaldehyde semicarbazone derivatives bearing in vitro anti-tumor activity toward kidney tumor cells (TK-10): Crystal structure of [V VO 2(5-bromosalicylaldehyde semicarbazone)]

    Journal of Inorganic Biochemistry, Vol. 99, Núm. 2, pp. 443-451

2004

  1. 1,2,4-Triazine N-oxide derivatives: Studies as potential hypoxic cytotoxins. Part II

    Archiv der Pharmazie, Vol. 337, Núm. 5, pp. 247-258

  2. 1,2,4-Triazine N-oxide derivatives: Studies as potential hypoxic cytotoxins. Part III

    Archiv der Pharmazie, Vol. 337, Núm. 5, pp. 271-280