Josune
Orbe Lopategui
Profesional Investigadora
Agustina
Salicio
Publicaciones en las que colabora con Agustina Salicio (6)
2019
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MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes
Translational Stroke Research, Vol. 10, Núm. 4, pp. 389-401
2018
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Phenotypic Screening to Discover Novel Chemical Series as Efficient Antihemorrhagic Agents
ACS Medicinal Chemistry Letters, Vol. 9, Núm. 5, pp. 428-433
2017
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New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator
Cardiovascular Research, Vol. 113, Núm. 10, pp. 1219-1229
2015
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Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury
Blood, Vol. 126, Núm. 7, pp. 915-919
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Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: From hit identification to an optimized lead
Journal of Medicinal Chemistry, Vol. 58, Núm. 5, pp. 2465-2488
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Discovery and Safety Profiling of a Potent Preclinical Candidate, (4-[4-[[(3 R)-3-(Hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]- N -methylbenzamide) (CM-352), for the Prevention and Treatment of Hemorrhage
Journal of Medicinal Chemistry, Vol. 58, Núm. 7, pp. 2941-2957