(FC) Bioquímica y Genética
Departamento académico
Leire
Garate Iturriagagoitia
Investigadora Colaboradora
Publicaciones en las que colabora con Leire Garate Iturriagagoitia (22)
2024
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Epigenetic-based differentiation therapy for Acute Myeloid Leukemia
Nature Communications, Vol. 15, Núm. 1
2022
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Landscape and clinical significance of long noncoding RNAs involved in multiple myeloma expressed fusion transcripts
American Journal of Hematology
2021
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Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma
Leukemia, Vol. 35, Núm. 5, pp. 1438-1450
2020
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Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma
Genome Research, Vol. 30, Núm. 9, pp. 1217-1227
2018
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Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces
Journal of Medicinal Chemistry, Vol. 61, Núm. 15, pp. 6546-6573
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Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy
Journal of Medicinal Chemistry, Vol. 61, Núm. 15, pp. 6518-6545
2012
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Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia (Blood (2007) 109, 8 (3462-3469))
Blood
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Preclinical activity of LBH589 alone or in combination with chemotherapy in a xenogeneic mouse model of human acute lymphoblastic leukemia
Leukemia, Vol. 26, Núm. 7, pp. 1517-1526
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TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia
PLoS ONE, Vol. 7, Núm. 2
2011
2009
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Epigenetic regulation of MicroRNAs in acute lymphoblastic leukemia
Journal of Clinical Oncology, Vol. 27, Núm. 8, pp. 1316-1322
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Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia
Cancer Research, Vol. 69, Núm. 10, pp. 4443-4453
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MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations
Molecular Cancer, Vol. 8, pp. 69
2008
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BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia
British Journal of Haematology, Vol. 142, Núm. 4, pp. 571-582
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Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth
Molecular Cancer Research, Vol. 6, Núm. 12, pp. 1830-1840
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Resistance to Imatinib Mesylate-induced apoptosis in acute lymphoblastic leukemia is associated with PTEN down-regulation due to promoter hypermethylation
Leukemia Research, Vol. 32, Núm. 5, pp. 709-716
2007
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Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia
Blood, Vol. 109, Núm. 8, pp. 3462-3469
2006
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ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia
Oncogene, Vol. 25, Núm. 13, pp. 1862-1870
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Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia
International Journal of Cancer, Vol. 118, Núm. 8, pp. 1945-1953