Publicaciones en colaboración con investigadores/as de Universidad de la República (31)

2018

  1. Major barriers in Lean health care: an exploratory study in Uruguay

    International Journal of Lean Six Sigma, Vol. 9, Núm. 4, pp. 466-481

2017

  1. Development, validation and application of a GC–MS method for the simultaneous detection and quantification of neutral lipid species in Trypanosoma cruzi

    Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Vol. 1061-1062, pp. 225-232

2016

  1. Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity

    Bioorganic and Medicinal Chemistry Letters, Vol. 26, Núm. 3, pp. 903-906

2013

  1. Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents

    European Journal of Medicinal Chemistry, Vol. 66, pp. 324-334

  2. Phenazine N,N′-dioxide scaffold as selective hypoxic cytotoxin pharmacophore. Structural modifications looking for further DNA topoisomerase II-inhibition activity

    MedChemComm, Vol. 4, Núm. 3, pp. 595-607

2011

  1. 3-trifluoromethylquinoxaline N, N′-dioxides as anti-Trypanosomatid agents. Identification of optimal anti- T. cruzi agents and mechanism of action studies

    Journal of Medicinal Chemistry, Vol. 54, Núm. 10, pp. 3624-3636

  2. Genetic toxicology and preliminary in vivo studies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents

    Drug and Chemical Toxicology, Vol. 34, Núm. 3, pp. 285-293

2010

  1. Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 14, pp. 5391-5399

  2. Structural modifications on the phenazine N,N′-dioxide-scaffold looking for new selective hypoxic cytotoxins

    European Journal of Medicinal Chemistry, Vol. 45, Núm. 11, pp. 5362-5369

  3. Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation

    Bioorganic and Medicinal Chemistry, Vol. 18, Núm. 12, pp. 4433-4440

2009

  1. Cytotoxic, mutagenic and genotoxic effects of new anti-T. cruzi 5-phenylethenylbenzofuroxans. Contribution of phase I metabolites on the mutagenicity induction

    Toxicology Letters, Vol. 190, Núm. 2, pp. 140-149

2008

  1. Antitumoral effect of phenazine N5,N10-dioxide derivatives on Caco-2 cells

    Chemical Research in Toxicology, Vol. 21, Núm. 8, pp. 1578-1585

  2. New copper-based complexes with quinoxaline N1,N4-dioxide derivatives, potential antitumoral agents

    Journal of Inorganic Biochemistry, Vol. 102, Núm. 1, pp. 119-126

2007

  1. Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure-activity relationships

    Bioorganic and Medicinal Chemistry, Vol. 15, Núm. 10, pp. 3356-3367

2006

  1. Design and evaluation of "3 + 1" mixed ligand oxorhenium and oxotechnetium complexes bearing a nitroaromatic group with potential application in nuclear medicine oncology

    European Journal of Medicinal Chemistry, Vol. 41, Núm. 10, pp. 1144-1152

  2. Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies

    Bioorganic and Medicinal Chemistry, Vol. 14, Núm. 10, pp. 3467-3480

  3. Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins: Part II. Structure-activity relationship studies

    Medicinal Chemistry, Vol. 2, Núm. 5, pp. 511-521

  4. Selective hypoxia-cytotoxins based on vanadyl complexes with 3-aminoquinoxaline-2-carbonitrile-N1,N4-dioxide derivatives

    Journal of Inorganic Biochemistry, Vol. 100, Núm. 8, pp. 1358-1367

2005

  1. Novel Cu(II) quinoxaline N1,N4-dioxide complexes as selective hypoxic cytotoxins

    European Journal of Medicinal Chemistry, Vol. 40, Núm. 5, pp. 473-480

  2. Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins

    Journal of Medicinal Chemistry, Vol. 48, Núm. 1, pp. 21-23