(FM) Unidad de Medicina Traslacional
Departamento académico
Xabier
Aguirre Ena
Profesional Investigador
Xabier Aguirre Ena-rekin lankidetzan egindako argitalpenak (25)
2024
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Epigenetic-based differentiation therapy for Acute Myeloid Leukemia
Nature Communications, Vol. 15, Núm. 1
2023
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Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
Nature Medicine, Vol. 29, Núm. 3, pp. 632-645
2022
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NGS-Based Molecular Karyotyping of Multiple Myeloma: Results from the GEM12 Clinical Trial
Cancers, Vol. 14, Núm. 20
2021
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Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma
Leukemia, Vol. 35, Núm. 5, pp. 1438-1450
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Endogenous retroelement activation by epigenetic therapy reverses the warburg effect and elicits mitochondrial-mediated cancer cell death
Cancer Discovery, Vol. 11, Núm. 5, pp. 1268-1285
2020
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Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma
Leukemia, Vol. 34, Núm. 11, pp. 3007-3018
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Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma
Blood, Vol. 136, Núm. 2, pp. 199-209
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Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination
Leukemia, Vol. 34, Núm. 2, pp. 589-603
2019
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Genotyping and Sequencing
Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition (Elsevier), pp. 33-39
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NGS data analysis process
Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition (Elsevier), pp. 33-39
2018
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Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces
Journal of Medicinal Chemistry, Vol. 61, Núm. 15, pp. 6546-6573
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Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy
Journal of Medicinal Chemistry, Vol. 61, Núm. 15, pp. 6518-6545
2017
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Differentiation stage of myeloma plasma cells: Biological and clinical significance
Leukemia, Vol. 31, Núm. 2, pp. 382-392
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Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies
Nature Communications, Vol. 8
2016
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Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics
Nature Communications, Vol. 7
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Use of human pharyngeal and palatine tonsils as a reservoir for the analysis of B-cell ontogeny in 10 paired samples
Clinical Otolaryngology, Vol. 41, Núm. 5, pp. 606-611
2015
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Whole-genome fingerprint of the DNA methylome during human B cell differentiation
Nature Genetics, Vol. 47, Núm. 7, pp. 746-756
2012
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Epigenetic regulation of miRNA genes in acute leukemia
Leukemia, Vol. 26, Núm. 3, pp. 395-403
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Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice
Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Núm. 26, pp. 10534-10539
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High-throughput sequencing analysis of the chromosome 7q32 deletion reveals IRF5 as a potential tumour suppressor in splenic marginal-zone lymphoma
British Journal of Haematology, Vol. 158, Núm. 6, pp. 712-726