Colonic metabolism of phenolic compoundsfrom in vitro to in vivo approaches
- Mosele, Juana Inés
- Maria Alba Macia Puig Director
- María José Motilva Casado Director
Defence university: Universitat de Lleida
Fecha de defensa: 15 April 2016
- Daniele Del Rio Chair
- Iziar Amaia Ludwig Sanz Orrio Secretary
- María Rodríguez-Palmero Committee member
Type: Thesis
Abstract
Phenolic compounds are a group phytochemicals widely but not uniform distributed in the plant kingdom. These compounds have generated great expectations in the scientific community as natural therapeutics due to their antioxidant, anti-inflammatory and anticarcinogenic properties. Initial attention was concentrated to study the bioavailability of the native compounds present in the food. Nevertheless, their aparent low bioavailability has awake the possibility to contemplate other related metabolites rather than the original forms. In the obstinacy to really cover the general metabolism of phenolic compounds in the human body, their colonic fate has gained a central role. The different works that make up the body of this Doctoral Thesis are focused in the study of the colonic metabolism of the more representative phenolic compounds present in three plan-based products. The products concerned were enriched olive oil in its own phenolic compounds and in combination with thyme phenolic compounds, pomegranate and Arbutus unedo fruit. In vitro fermentations and human interventions were conducted with the purpose of exploring the fate of phenolic compounds in the gut.