Role of aquaporins in the improvement of adiposity and non-alcoholic fatty liver disease after bariatric surgery

  1. Méndez Giménez de los Galanes, Leire
Supervised by:
  1. Gema Frühbeck Martínez Director
  2. Amaia Rodríguez Co-director

Defence university: Universidad de Navarra

Defense date: 23 June 2017

Committee:
  1. Piero Portincasa Chair
  2. María Angela Burrell Bustos Secretary
  3. F. Javier Salvador Rodríguez Committee member
  4. Miguel Antonio López Pérez Committee member
  5. Miriam Echevarría Irusta Committee member
Centro / Instituto integral de la Universidad de Navarra: Cancer Center Clínica Universidad de Navarra (CCUN)
Centro académico (Área Salud, Experimentales y Técnicas): Facultad de Medicina (FM)
Centro clínico de la Universidad de Navarra: Clínica Universidad de Navarra (CUN)
Departamento académico (Área Salud, Experimentales y Técnicas): (FM) Endocrinología y Nutrición
Organización: Universidad de Navarra

Type: Thesis

Teseo: O146755 DIALNET HANDLE: https://hdl.handle.net/10171/43753
Dadun. Depósito Académico Digital de la Universidad de Navarra: lock_openOpen access Handle

Abstract

The regulation of aquaglyceroporins in metabolic tissues is important for the control of fat accumulation, glucose homeostasis and insulin secretion. Obesity and insulin resistance are associated with changes in the expression of adipose tissue aquaglyceroporins, one of the main sources of plasma glycerol. Moreover, the coordinated regulation of aquaglyceroporins in adipose tissue and liver is impaired in both pathologies. The overall aim of the present thesis was to analyze whether the altered expression of aquaglyceroporins in adipose tissue, liver and pancreas is recovered in diet-induced obese rats submitted to two different bariatric surgery techniques, namely sleeve gastrectomy or gastric plication.