Sex differences in ochratoxin A nephrotoxicityA molecular approach to the mechanism of action

  1. Pastor Castro, Laura
Supervised by:
  1. Adela López de Cerain Salsamendi Director
  2. Ariane Vettorazzi Armental Co-director

Defence university: Universidad de Navarra

Fecha de defensa: 05 July 2017

Committee:
  1. María Pilar Lostao Crespo Chair
  2. Paul Cordero Secretary
  3. Francisco Javier Campión Zabalza Committee member
  4. Fermín Ignacio Milagro Yoldi Committee member
  5. Eduardo de la Peña Torres Committee member
Centro académico (Área Salud, Experimentales y Técnicas): Facultad de Farmacia y Nutrición (FFN)
Departamento académico (Área Salud, Experimentales y Técnicas): (FFN) Ciencias Farmacéuticas
Organización: Universidad de Navarra

Type: Thesis

Teseo: 122795 DIALNET HANDLE: https://hdl.handle.net/10171/43768
Dadun. Depósito Académico Digital de la Universidad de Navarra: lock_openOpen access Handle

Abstract

This work is included in the line of research carried out in Toxicology which studies the mycotoxin ochratoxin A (OTA) from the point of view of its mechanism of action. OTA causes various toxic effects, such as nephrotoxicity, hepatotoxicity, immunosuppression, neurotoxicity and teratogenicity. However, the main issue concerning OTA effect is its carcinogenic potential in kidney, the target organ. The aim of this research project was to explore the impact of sex on OTA-induced gene expression response in order to determine the key events that might be involved in the early events of the carcinogenic process.