Immunomodulation and metabolismpossible role of lactoferrin
- Moreno Navarrete, J. M.
- José Manuel Fernández Real Lemos Directeur/trice
Université de défendre: Universitat de Girona
Fecha de defensa: 20 juin 2011
- Antonio Zorzano Olarte President
- Victoria Catalán Goñi Secrétaire
- Carmen Carretero Romay Rapporteur
- Joan Vendrell Ortega Rapporteur
- Maria Vilanova Brugués Rapporteur
Type: Thèses
Résumé
To gain insight in the relationship between innate immune system and metabolic disease, we aimed to investigate the effects of lactoferrin in obesity-related metabolic disturbances. Circulating lactoferrin concentration was significantly decreased in subjects with altered glucose tolerance (AGT) and associated negatively with obesity-related metabolic disturbances. The SNPs-induced aminoacidic changes in lactoferrin N-terminus region were associated with a low atherogenic lipid profile. Lactoferrin production in neutrophils decreased significatively in aging, chronic low-grade inflammation and type 2 diabetes. In vitro, lactoferrin increased insulin signaling pathway, even under insulin resistance conditions and displayed dual effects on adipogenesis (antiadipogenic in 3T3-L1 and adipogenic in human adipocytes). In conclusion, lactoferrin might play a potential protective role against insulin resistance and obesity related metabolic disturbances.