Immunomodulation and metabolismpossible role of lactoferrin
- Moreno Navarrete, J. M.
- José Manuel Fernández Real Lemos Director
Universidade de defensa: Universitat de Girona
Fecha de defensa: 20 de xuño de 2011
- Antonio Zorzano Olarte Presidente/a
- Victoria Catalán Goñi Secretaria
- Carmen Carretero Romay Vogal
- Joan Vendrell Ortega Vogal
- Maria Vilanova Brugués Vogal
Tipo: Tese
Resumo
To gain insight in the relationship between innate immune system and metabolic disease, we aimed to investigate the effects of lactoferrin in obesity-related metabolic disturbances. Circulating lactoferrin concentration was significantly decreased in subjects with altered glucose tolerance (AGT) and associated negatively with obesity-related metabolic disturbances. The SNPs-induced aminoacidic changes in lactoferrin N-terminus region were associated with a low atherogenic lipid profile. Lactoferrin production in neutrophils decreased significatively in aging, chronic low-grade inflammation and type 2 diabetes. In vitro, lactoferrin increased insulin signaling pathway, even under insulin resistance conditions and displayed dual effects on adipogenesis (antiadipogenic in 3T3-L1 and adipogenic in human adipocytes). In conclusion, lactoferrin might play a potential protective role against insulin resistance and obesity related metabolic disturbances.