Alteraciones moleculares relacionadas con el carcinoma medular de tiroidesestudio mediante inmunohistoquímica y tissue-microarrays
- GALELL VICENTE, MARIA PILAR
- Mario Encimas Martín Co-director
- Xavier Matías-Guiu Guía Co-director
Defence university: Universitat de Lleida
Fecha de defensa: 21 March 2014
- Francisco Javier Pardo Mindán Chair
- Judit Pallarés Quixal Secretary
- Javier Ortego Fernandez de Retama Committee member
Type: Thesis
Abstract
Abstract Medullary Thyroid Carcinoma (MTC) is a relatively rare malignant tumour with C-cell differentiation. 50% of sporadic MTC cases do not exhibit RET mutations. Sprouty is a RET antagonist. Thyroid Paraganglioma (TP) is one of the tumours associated with differential diagnosis. Alterations to several of the genes involved in MTC play an important role in tumoural progression and differential diagnosis. Three MTC-related studies using immunohistochemistry and tissue-arrays were conducted. One of these showed that NF-kB proteins are frequently active in MTC, as are the target genes FLIP and BcL-xL. In a second, a group of young adult mice with selectively deleted spry1 developed C-cell hyperplasia. Following the third, we propose the mandatory use of an immunohistochemical battery of 7 proteins for differential diagnosis between MTC and neck and head paragangliomas, conducting reliability tests to check their reliability on 4 TP cases.