Raw data for "Development and characterization of a non-human primate model of disseminated synucleinopathy"

  1. Rico, Alberto J. 1
  2. Corcho, Almudena 2
  3. Julia, Chocarro 2
  4. Ariznabarreta, Goiaz 2
  5. Roda, Elvira 2
  6. Adriana, Honrubia 2
  7. Patricia, Arnaiz 2
  8. Lanciego, Jose L. 3
  1. 1 CNS Gene Therapy Program, Center for Appplied Medical Research (CIMA), Univiersity of Navarra, Pamplona, Spain
  2. 2 CNS Gene Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra
  3. 3 CNS Gene Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain
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Éditeur: Zenodo

Année de publication: 2023

Type: Dataset

CC BY 4.0

DOI: 10.5281/ZENODO.10390250 lock_openAccès ouvert editor

Résumé

In this study, the performance and biodistribution of the retrogradely-spreading AAV9-SynA53T vector was evaluated in the NHP brain. Conducted intraparenchymal deliveries of viral suspensions in the left putamen gave rise to a disseminated synucleinopathy in a circuit-specific basis.