Ocratoxina A en plasma humanonuevos datos de exposición en España

  1. Pérez de Obanos, A.
  2. López de Ceraín, A.
  3. Jiménez, A.M.
  4. González Peñas, E. 1
  5. Bello, J.
  1. 1 Universidad de Navarra
    info

    Universidad de Navarra

    Pamplona, España

    ROR https://ror.org/02rxc7m23

Revista:
Revista de toxicología

ISSN: 0212-7113

Año de publicación: 2001

Volumen: 18

Número: 1

Páginas: 19-23

Tipo: Artículo

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Otras publicaciones en: Revista de toxicología

Resumen

In order to study the occurrence of Ochratoxin A in a southern region of Spain, Granada, 83 blood plasma samples collected from women have been analysed. The method of analysis is based on a liquid-liquid extraction followed by a High Performance Liquid Cromatographic (HPLC) analysis with fluorescence detection. The method has been validated and a detection limit of 0.21 ng/mL has been obtained. Ochratoxin A has been detected in 72% of the samples. The mean value was 0.63 ng/mL, with a standard deviation of 0.41 ng/mL and a range of concentrations from 0.11 ng/mL to 6.96 ng/mL. These results are similar to those found in other northern and medium regions of Spain, and to those found in the surrounding countries. Statistical analysis by Kruskal-Wallis (n = 70; χ2= 4.591; p = 0.597), did not show any difference between plasma levels and the season when the samples were collected. These findings prove the general and wide exposition to Ochratoxin A of Spanish population, although the Daily Ochratoxin A Intake calculated from the mean value obtained in this study, is lower than the maximum level recommended by the Joint FAO/WHO Expert Committee on Food Additives.

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