José Ángel
Martínez Climent
Investigador Senior
Publications (138) José Ángel Martínez Climent publications
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2026
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Integrated Single-Cell and Spatial Multi-Omics of Clonal Precursors and Immune Niches in Germinal Center Lymphomas
Cancers, Vol. 18, Núm. 7
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Mezigdomide combined with bortezomib disrupts the cell cycle and elicits superior antitumor effects in multiple myeloma
Blood Neoplasia, Vol. 3, Núm. 1
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Selective B-cell subset depletion underlies increased infection risk in patients with MM treated with anti-BCMA vs anti-GPRC5D bsAbs
Blood, Vol. 147, Núm. 10, pp. 1070-1082
2025
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Characterization of the bone marrow architecture of multiple myeloma using spatial transcriptomics
Communications Biology, Vol. 8, Núm. 1
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Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors
Molecular Cancer, Vol. 24, Núm. 1
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Editorial special issue: Frontiers in cancer, obesity and metabolism
Journal of Physiology and Biochemistry
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Fatty Acid Metabolism Provides an Essential Survival Signal in OxPhos and BCR DLBCL Cells
Biomedicines, Vol. 13, Núm. 3
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IL-10 from tumoral B cells modulates the diffuse large B-cell lymphoma microenvironment and response to immunotherapy
Blood, Vol. 145, Núm. 23, pp. 2746-2761
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Loss of CYLD promotes splenic marginal zone lymphoma
HemaSphere, Vol. 9, Núm. 3
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Metabolic Heterogeneity in Diffuse Large B-Cell Lymphoma Cells Reveals an Innovative Antimetabolic Combination Strategy
Cancers, Vol. 17, Núm. 3
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Reprogramming glutamine metabolism enhances BCMA-CAR T-cell fitness and therapeutic efficacy in multiple myeloma
Blood, Vol. 146, Núm. 24, pp. 2931-2944
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SOX4 in chronic lymphocytic leukaemia: the forgotten transcription factor
Blood Research, Vol. 60, Núm. 1
2024
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Bone Marrow Spatial Transcriptomics Reveals a Myeloma Cell Architecture with Dysfunctional T-Cell Distribution, Neutrophil Traps, and Inflammatory Signaling
BIORXIV
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Not so natural, not so killers
Blood
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Round Table Discussion on Optimal Clinical Trial Design in Precursor Multiple Myeloma
Blood cancer discovery, Vol. 5, Núm. 3, pp. 146-152
2023
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Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation
Blood, Vol. 141, Núm. 9, pp. 1047-1059
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Chronic docosahexaenoic acid supplementation improves metabolic plasticity in subcutaneous adipose tissue of aged obese female mice
Journal of Nutritional Biochemistry, Vol. 111
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Differential remodeling of subcutaneous white and interscapular brown adipose tissue by long-term exercise training in aged obese female mice
Journal of Physiology and Biochemistry, Vol. 79, Núm. 2, pp. 451-465
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Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
Nature Communications, Vol. 14, Núm. 1
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Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
Nature Medicine, Vol. 29, Núm. 3, pp. 632-645